{"id":"W4414465438","doi":"10.1158/2326-6074.cimm25-b001","title":"Abstract B001: Leveraging peripheral leukocyte recruitment to improve efficacy and mitigate toxicities following checkpoint blockade","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Blockade; Cytotoxic T cell; Immune checkpoint; T cell; CD8; Immune system; Cancer immunotherapy; Immunotherapy; Effector","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001016509,0.0003026013,0.0006506913,0.0005795438,0.0004960592,0.00011259,0.0002928746,0.0002286821,0.0001848692],"category_scores_gemma":[0.0003906638,0.0002841784,0.0001821513,0.0005400526,0.0005389621,0.0001133365,0.0002978389,0.001026077,0.0000245285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001107516,"about_ca_system_score_gemma":0.001022198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001388822,"about_ca_topic_score_gemma":0.00006645788,"domain_scores_codex":[0.9971228,0.0002252251,0.0004764161,0.0007025169,0.0003996744,0.001073404],"domain_scores_gemma":[0.9984688,0.0004042044,0.00006005437,0.0006494469,0.0002306312,0.0001868988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006069634,0.0001612558,0.002603154,0.0002907513,0.0008960482,0.0002140852,0.003263445,0.00002009616,0.820804,0.00004619861,0.001899438,0.1637319],"study_design_scores_gemma":[0.008920043,0.001263517,0.2626266,0.002257779,0.000156712,0.0001014252,0.005362131,0.00007369948,0.5301997,0.0001298776,0.1883825,0.0005260676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9386077,0.04417044,0.00001334037,0.01312773,0.0007806704,0.001546601,0.000007163011,0.0000840484,0.001662313],"genre_scores_gemma":[0.9793713,0.005066452,0.000116707,0.0008105392,0.0003553088,0.001044379,0.000009553475,0.0000476675,0.01317807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2906043,"threshold_uncertainty_score":0.999961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08841217000830207,"score_gpt":0.4087061111463385,"score_spread":0.3202939411380364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}