{"id":"W4414465452","doi":"10.1158/2326-6074.cimm25-b012","title":"Abstract B012: Bromodomain and extra-terminal domain (BET) as a therapeutic target in a mouse model of secondary hemophagocytic lymphohistiocytosis (HLH)","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Bromodomain; Spleen; Cytotoxic T cell; BET inhibitor; Perforin; Adoptive cell transfer; Anemia; Lymphocyte; Peripheral blood mononuclear cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003095649,0.0007294036,0.0007585233,0.0006876388,0.0002389918,0.0003876086,0.000411056,0.0008069729,0.002353945],"category_scores_gemma":[0.00008860244,0.0002210454,0.0004162941,0.0003222318,0.0004615007,0.0003689814,0.0001690304,0.001932173,0.0006655891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002986444,"about_ca_system_score_gemma":0.0003041963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004631116,"about_ca_topic_score_gemma":0.0006159284,"domain_scores_codex":[0.9997277,0.00004059879,0.00002204495,0.00005214236,0.00006713926,0.0000903954],"domain_scores_gemma":[0.9998724,0.00001094911,0.00002952506,0.0000109746,0.000008904619,0.00006714477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003434264,0.001480739,0.0001795832,0.0001275254,0.00001930689,0.0001060037,0.00002503618,0.0001878056,0.9907132,0.0002339684,0.0003674653,0.003125146],"study_design_scores_gemma":[0.001311847,0.0193541,0.003429726,0.00003723902,0.0001026583,0.0005130419,0.0000891743,0.001711534,0.9677722,0.0001434454,0.0055169,0.00001808323],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9910882,0.001879668,0.00215947,0.0003701985,0.0002364702,0.0001977004,0.001467555,0.000240069,0.002360771],"genre_scores_gemma":[0.985308,0.001598438,0.003468884,0.0002164402,0.00006022664,0.0004386402,0.001868865,0.00003996371,0.007000458],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002353945,"threshold_uncertainty_score":0.007874727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04491956817156655,"score_gpt":0.3739006009824927,"score_spread":0.3289810328109261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}