{"id":"W4414465467","doi":"10.1158/2326-6074.cimm25-b011","title":"Abstract B011: Mast cells mediate tumor-suppressive effects in head and neck cancer through immune-microenvironmental regulation","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Head and neck squamous-cell carcinoma; Downregulation and upregulation; Tumor microenvironment; Cytokine; Mast cell; Chemokine; Immune system; Interleukin 33; Immunotherapy; Cell cycle","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005109851,0.000290147,0.0005314221,0.0003487239,0.0003964879,0.0000321416,0.0004016492,0.0004155582,0.00235064],"category_scores_gemma":[0.00004487861,0.0002790924,0.00007122772,0.0003835319,0.001913458,0.0001731432,0.00045166,0.001295215,0.0002085786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000444628,"about_ca_system_score_gemma":0.0002348837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004461801,"about_ca_topic_score_gemma":0.0008144783,"domain_scores_codex":[0.9972445,0.0005174247,0.0004758074,0.0006866716,0.00008926968,0.0009863008],"domain_scores_gemma":[0.9989449,0.0003478088,0.0001294765,0.0004646622,0.00008493924,0.00002825555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006620791,0.0001827443,0.01322933,0.0001910293,0.0002070965,0.00003961308,0.0009608135,0.00002687717,0.9673663,0.0006015405,0.003496091,0.01303651],"study_design_scores_gemma":[0.004722448,0.0001848615,0.4628349,0.0005302453,0.0000297956,0.00001802466,0.0004553397,0.000009583393,0.4789801,0.0006878887,0.05126274,0.0002840301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8690255,0.1255916,0.00001328628,0.0008662479,0.001232542,0.0007065243,0.00007320901,0.0000305272,0.002460562],"genre_scores_gemma":[0.979064,0.01015654,0.00003585216,0.0001398778,0.000040379,0.0005063459,0.00008824466,0.00003018273,0.009938574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4883861,"threshold_uncertainty_score":0.9999661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0179766665746558,"score_gpt":0.3154393146258206,"score_spread":0.2974626480511648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}