{"id":"W4414466003","doi":"10.1158/2326-6074.cimm25-b004","title":"Abstract B004: Route dependent T-cell activation by mRNA cluster therapies","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Peripheral blood mononuclear cell; Immunogenicity; Flow cytometry; Messenger RNA; Cell; T cell; Immunotherapy; CD8; Cancer vaccine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001420357,0.0002186809,0.000390203,0.0006389248,0.0003212483,0.00008533044,0.0004913394,0.0003735361,0.007206402],"category_scores_gemma":[0.0001620316,0.0001919266,0.0001185898,0.0007953858,0.0005939587,0.0001506933,0.000280322,0.001890645,0.0002264037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001116453,"about_ca_system_score_gemma":0.001064549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001920857,"about_ca_topic_score_gemma":0.0001027289,"domain_scores_codex":[0.9969571,0.0003585283,0.00035308,0.0005858314,0.0007768401,0.0009685789],"domain_scores_gemma":[0.9977576,0.0005897878,0.00005937921,0.0008231652,0.0006610124,0.0001090842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002464903,0.0002782587,0.008289086,0.0001276187,0.0004661818,0.00001467629,0.0003832859,0.000003926602,0.8761973,0.00008415427,0.03571983,0.07597078],"study_design_scores_gemma":[0.005314747,0.0003924345,0.04795821,0.0002253162,0.00002627376,0.000009814951,0.0009276779,0.00004209298,0.6844851,0.0004686649,0.2599384,0.0002112616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9188957,0.01653462,0.0000801547,0.01737057,0.0003757936,0.001310983,0.00002452105,0.00009070237,0.045317],"genre_scores_gemma":[0.83821,0.005714277,0.00003027085,0.0006570776,0.0001464547,0.0004826727,0.00005211221,0.00004356812,0.1546635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2242185,"threshold_uncertainty_score":0.9937012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05301857479781626,"score_gpt":0.4049490759040293,"score_spread":0.3519305011062131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}