{"id":"W4414477188","doi":"10.1016/j.rpth.2025.103191","title":"Andexanet alfa for the reversal of the low-molecular-weight heparin enoxaparin","year":2025,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Venous Thromboembolism Diagnosis and Management","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"Boston Scientific Corporation; CSL Behring; F. Hoffmann-La Roche; Sanofi; AstraZeneca Canada; Norgine; AstraZeneca; Bristol-Myers Squibb","keywords":"Heparin; Hemostasis; Anticoagulant; Drug; Clinical trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008253413,0.0004389416,0.0007793631,0.0001806665,0.0002250712,0.000441874,0.0002748155,0.000423871,0.003121099],"category_scores_gemma":[0.0006275334,0.0001551237,0.0005888913,0.0001290576,0.0004137525,0.0002990111,0.000198522,0.001131764,0.0003907411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002489623,"about_ca_system_score_gemma":0.0005213723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002279783,"about_ca_topic_score_gemma":0.0004631225,"domain_scores_codex":[0.9996238,0.0001926564,0.00003732863,0.00004924246,0.00004995904,0.00004703775],"domain_scores_gemma":[0.9995649,0.0001022373,0.0001428127,0.0000404293,0.00003583683,0.000113615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.5560895,0.0283389,0.009860536,0.001944009,0.001501902,0.0006226139,0.0002608605,0.0006611666,0.1232605,0.000915511,0.003834085,0.2727105],"study_design_scores_gemma":[0.2741853,0.6462992,0.02283797,0.000222881,0.001360176,0.002409493,0.0001038567,0.001054493,0.03374046,0.0003560325,0.01738284,0.00004723859],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896744,0.007279241,0.0005051742,0.0003304112,0.0001602851,0.0005414792,0.0002012465,0.00002385913,0.001283791],"genre_scores_gemma":[0.9921826,0.003424027,0.001069065,0.0004161923,0.0001919275,0.0004969425,0.0002828125,0.000005040087,0.001931376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003121099,"threshold_uncertainty_score":0.01044112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09530509345296602,"score_gpt":0.4449117539749708,"score_spread":0.3496066605220048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}