{"id":"W4414477319","doi":"10.1016/j.isci.2025.113630","title":"Adjuvants and MHCII modulate the immunogenicity of subdominant epitopes in Plasmodium vivax Duffy binding protein","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; Canada Foundation for Innovation; National Institutes of Health; University of Alberta","keywords":"Subdominant; Epitope; Immunogenicity; Antigen; Immune system; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009827036,0.000237065,0.0001727619,0.00006827316,0.00008526629,0.0001161467,0.00009951447,0.0001140011,0.0006121306],"category_scores_gemma":[0.0001083563,0.00006780031,0.00006254918,0.00004839029,0.0001202681,0.0001197394,0.000118155,0.0003141066,0.0001007938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001326165,"about_ca_system_score_gemma":0.0001470819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003310554,"about_ca_topic_score_gemma":0.0005730347,"domain_scores_codex":[0.9999433,0.00001411908,0.000003514436,0.000008600286,0.00001080172,0.00001977375],"domain_scores_gemma":[0.9999572,0.00001130367,0.00001155141,0.000002710841,0.000004368182,0.00001279047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007506435,0.00002653807,0.0001114977,0.00001589193,0.000001274626,0.00001331774,0.000009827463,0.00007399509,0.9988563,0.00005281498,0.000009045569,0.0007544747],"study_design_scores_gemma":[0.00003781542,0.001234166,0.004104455,0.000007075581,0.00001835798,0.0001580113,0.00003586785,0.002043316,0.9904113,0.0001027279,0.001842839,0.000004166781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987136,0.0003456852,0.0005680865,0.00002460171,0.000005165235,0.00001233523,0.00001583591,0.000005740423,0.0003089175],"genre_scores_gemma":[0.9982206,0.0002849111,0.0009429975,0.00002932745,0.000005611106,0.000009422859,0.00004440624,0.0000048894,0.0004578121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006121306,"threshold_uncertainty_score":0.002047837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253253289155937,"score_gpt":0.2674096608262919,"score_spread":0.2548771279347326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}