{"id":"W4414478783","doi":"10.3390/receptors4040018","title":"Functional HER1/HER2-Expressing Murine Tumor Models for Preclinical Evaluation of Targeted Therapies","year":2025,"lang":"en","type":"article","venue":"Receptors","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Université de Montpellier","keywords":"Monoclonal antibody; Tyrosine kinase; Transduction (biophysics); Receptor tyrosine kinase; Carcinogenesis; Immunotherapy; Signal transduction; Receptor; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007814394,0.001214779,0.0003718983,0.0009432452,0.0002304779,0.0005128171,0.0005703073,0.0006289486,0.003187039],"category_scores_gemma":[0.0002003045,0.0002119193,0.0004346539,0.0003205038,0.0002995858,0.0005906341,0.0002682237,0.001692125,0.0008699429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006252049,"about_ca_system_score_gemma":0.0003731519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003782366,"about_ca_topic_score_gemma":0.0007592475,"domain_scores_codex":[0.9996213,0.00007663644,0.00003850848,0.00006027472,0.0001229991,0.00008036564],"domain_scores_gemma":[0.9996698,0.00005061433,0.0001052463,0.00005107459,0.00004543777,0.00007784151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002773423,0.000460934,0.0002561919,0.00009666937,0.00001373126,0.00005010963,0.00002505968,0.0003596025,0.9957321,0.0004655397,0.0003073679,0.00195529],"study_design_scores_gemma":[0.00007960425,0.002184426,0.001116076,0.00002356081,0.0000536358,0.0003354057,0.00002408169,0.001329223,0.9893702,0.000144028,0.005330768,0.000008991935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9487415,0.004992259,0.03418242,0.0005065011,0.0002319745,0.0009167474,0.004403576,0.0005456028,0.005479425],"genre_scores_gemma":[0.9461818,0.004158173,0.03264025,0.0002216057,0.00005606422,0.001229245,0.005358357,0.0001611234,0.009993413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003187039,"threshold_uncertainty_score":0.01066166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1170074023747308,"score_gpt":0.4081572444266454,"score_spread":0.2911498420519146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}