{"id":"W4414487114","doi":"10.1097/jova.0000000000000124","title":"Trametinib Normalizes Angiopoietin-2 Levels and Successfully Treats Kaposiform Lymphangiomatosis","year":2025,"lang":"en","type":"article","venue":"Journal of Vascular Anomalies","topic":"Vascular Malformations and Hemangiomas","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"National Heart, Lung, and Blood Institute","keywords":"Lymphangiomatosis; Trametinib; Sirolimus; Consumptive Coagulopathy; Lymphatic system; Standard of care; Hematology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006323053,0.0002251352,0.0006597445,0.0007008591,0.0001735175,0.0001019904,0.0001490732,0.0001351477,0.0001182836],"category_scores_gemma":[0.0001098271,0.0001709566,0.0007856177,0.0004611752,0.0001209544,0.0003917607,0.00006187119,0.0001202465,0.000007596867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006909812,"about_ca_system_score_gemma":0.0001845919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000225368,"about_ca_topic_score_gemma":0.000008577761,"domain_scores_codex":[0.9983916,0.00005662403,0.0007154443,0.0001578348,0.0004022975,0.0002762381],"domain_scores_gemma":[0.9988402,0.00006938037,0.0002644934,0.0002882647,0.0003752706,0.0001624224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001385235,0.002647832,0.7317382,0.00446281,0.01801447,0.00113977,0.008870256,0.000101117,0.01977691,0.02395715,0.01347315,0.1744331],"study_design_scores_gemma":[0.01125131,0.001093668,0.8739248,0.001593517,0.004076657,0.00443271,0.002680121,0.0003675345,0.02647977,0.001104294,0.07242621,0.000569405],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783564,0.01275209,0.00153662,0.001564469,0.0001589746,0.0002255032,0.000007344102,0.00003090845,0.005367739],"genre_scores_gemma":[0.9931412,0.0008044603,0.004889552,0.0003600161,0.00012518,0.000007453923,0.000006050412,0.00002030833,0.0006457319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1738636,"threshold_uncertainty_score":0.6971408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057198734244813,"score_gpt":0.2754450286862848,"score_spread":0.2648730413438367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}