{"id":"W4414491675","doi":"10.1158/2326-6074.cimm25-b009","title":"Abstract B009: Targeting PAR-2 improves tumor antigen presentation and primes the immune system for anti-PD-1 immunotherapy","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Espace pour la vie","funders":"","keywords":"Immunotherapy; Immune system; Tumor microenvironment; Flow cytometry; Cancer; Myeloid; Cancer immunotherapy; Cytokine; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002004934,0.0002490473,0.000509746,0.0003293421,0.0009271264,0.0001236776,0.0003352859,0.0001930819,0.00007446459],"category_scores_gemma":[0.0001724613,0.0001751005,0.0001809594,0.0006039625,0.001010629,0.0001451182,0.0001324858,0.0006245935,0.000005295213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003352951,"about_ca_system_score_gemma":0.0007847024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001431651,"about_ca_topic_score_gemma":0.00001915535,"domain_scores_codex":[0.997579,0.000234749,0.0005966302,0.0005242663,0.0003010974,0.0007641983],"domain_scores_gemma":[0.9979953,0.000669679,0.0001744093,0.0005990778,0.0005151891,0.00004629846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005331215,0.00008077266,0.007012452,0.0005708154,0.001197416,0.0000101603,0.000533033,9.836309e-7,0.929844,0.0004116137,0.00243444,0.0525731],"study_design_scores_gemma":[0.004881538,0.0003458643,0.5012782,0.000571497,0.00005280531,0.00003489857,0.003305384,0.0001234517,0.4478352,0.0001159633,0.04126239,0.0001928432],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7861344,0.2039215,0.00008337247,0.005550711,0.0007978189,0.002449498,0.00003050313,0.0000910955,0.0009410936],"genre_scores_gemma":[0.9857779,0.01075627,0.0001579782,0.0002197213,0.000203198,0.00107012,0.00003767214,0.00004463588,0.00173256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4942657,"threshold_uncertainty_score":0.7140393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03480508903454207,"score_gpt":0.3854354141521233,"score_spread":0.3506303251175813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}