{"id":"W4414491793","doi":"10.1158/2326-6074.cimm25-ia08","title":"Abstract IA08: Development and use of Engineered Regulatory T cells to treat Autoimmune Diseases","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immune system; Peripheral tolerance; Immune tolerance; Effector; T cell; Population; Immunotherapy; Antigen; Regulatory T cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002262143,0.0003887439,0.0001777263,0.0003012501,0.00007826343,0.0003270095,0.0003374519,0.0003704318,0.000927294],"category_scores_gemma":[0.000105984,0.00007591743,0.0002062963,0.0001310216,0.0001794492,0.0001381114,0.0001602688,0.0007117015,0.0006408008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001999298,"about_ca_system_score_gemma":0.0002835374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000279642,"about_ca_topic_score_gemma":0.000222104,"domain_scores_codex":[0.9998944,0.00001857109,0.000007776612,0.00002101641,0.00003651033,0.00002174367],"domain_scores_gemma":[0.9999522,0.000005223852,0.00001273058,0.000004462457,0.00001045395,0.00001488761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002670372,0.0001909633,0.0002633138,0.0001702325,0.00001591068,0.0001618946,0.00002467023,0.0006215642,0.9432477,0.0007748047,0.001089125,0.05317288],"study_design_scores_gemma":[0.0003162279,0.005030528,0.001632085,0.00007216227,0.00008124991,0.001388089,0.00001822046,0.002593179,0.9243668,0.0002607645,0.06422252,0.00001822402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8746755,0.04439069,0.05289419,0.001167315,0.001011318,0.0005746864,0.00125516,0.001199266,0.02283191],"genre_scores_gemma":[0.9347301,0.01316668,0.0355259,0.0005516445,0.0001822301,0.0004265686,0.001470372,0.0001082745,0.01383831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000927294,"threshold_uncertainty_score":0.003102124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06425826163130895,"score_gpt":0.3799349477968155,"score_spread":0.3156766861655066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}