{"id":"W4414491882","doi":"10.1158/2326-6074.cimm25-b019","title":"Abstract B019: CCR5 inhibition with leronlimab is associated with enhanced PD-L1 expression, ICI response, and long-term survival in metastatic TNBC.","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Attodyne (Canada)","funders":"","keywords":"Immunotherapy; Metastatic breast cancer; Clinical trial; Metastasis; Breast cancer; Adverse effect; Cancer; Antibody; Breast cancer metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002920979,0.0002118304,0.0003801371,0.0001286917,0.0001341329,0.0003289331,0.0001496529,0.0002108774,0.003735232],"category_scores_gemma":[0.0002560267,0.00007796183,0.0001882085,0.0001218546,0.0001626668,0.0001441675,0.000101268,0.0005584445,0.0005605727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003726311,"about_ca_system_score_gemma":0.0003713401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005751169,"about_ca_topic_score_gemma":0.0007468993,"domain_scores_codex":[0.9998965,0.00002359939,0.000007500038,0.00002278729,0.00002163389,0.00002797034],"domain_scores_gemma":[0.9998645,0.00002589739,0.0000310631,0.000009823657,0.00001358722,0.0000550643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03469428,0.002899619,0.02509605,0.000440701,0.0001931681,0.0005239787,0.0001023339,0.0006790728,0.8668664,0.0001464996,0.004156042,0.06420191],"study_design_scores_gemma":[0.005499347,0.081152,0.401689,0.00006662618,0.0004628347,0.004714168,0.0001906526,0.004893577,0.4877601,0.0001671088,0.01336129,0.00004324934],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963806,0.001203372,0.0002909545,0.00008985774,0.00002275036,0.0000597694,0.0005027617,0.00003779721,0.001412104],"genre_scores_gemma":[0.9968278,0.0001854452,0.0002659774,0.00008145162,0.00001553999,0.00004292252,0.001320022,0.000007252382,0.001253608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003735232,"threshold_uncertainty_score":0.01249564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05078881003570925,"score_gpt":0.3867239364335297,"score_spread":0.3359351263978205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}