{"id":"W4414491882","doi":"10.1158/2326-6074.cimm25-b019","title":"Abstract B019: CCR5 inhibition with leronlimab is associated with enhanced PD-L1 expression, ICI response, and long-term survival in metastatic TNBC.","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Attodyne (Canada)","funders":"","keywords":"Immunotherapy; Metastatic breast cancer; Clinical trial; Metastasis; Breast cancer; Adverse effect; Cancer; Antibody; Breast cancer metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001693032,0.0002674786,0.0005925574,0.0007240576,0.0002361165,0.00005313943,0.0001642299,0.0002237046,0.000480072],"category_scores_gemma":[0.0002472874,0.0001986095,0.00005292719,0.001316072,0.001064752,0.0001730201,0.00009935912,0.0009799341,0.000006887439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007535393,"about_ca_system_score_gemma":0.001414562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005234728,"about_ca_topic_score_gemma":0.001535733,"domain_scores_codex":[0.9971007,0.000604625,0.0004175662,0.0006209939,0.0005124033,0.0007437596],"domain_scores_gemma":[0.9980825,0.0007617699,0.0001274948,0.0004815128,0.0004674778,0.0000792974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1208963,0.0004939442,0.064834,0.0002272266,0.001109646,0.0003864534,0.001281201,0.000002453734,0.7980391,0.00001483574,0.0005923865,0.01212249],"study_design_scores_gemma":[0.01164547,0.001143816,0.8219699,0.002696257,0.00005493742,0.00002292784,0.000763266,0.000003361334,0.1612352,0.00003258346,0.0002430739,0.0001892903],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849865,0.009571912,0.00005310951,0.003562646,0.0001145445,0.0009386587,0.00003915847,0.00004726743,0.0006861822],"genre_scores_gemma":[0.9938537,0.002326314,0.00004143318,0.0003234117,0.00002249537,0.0004038624,0.00005253738,0.00003752417,0.002938751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7571359,"threshold_uncertainty_score":0.8099059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05078881003570925,"score_gpt":0.3867239364335297,"score_spread":0.3359351263978205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}