{"id":"W4414491888","doi":"10.1158/2326-6074.cimm25-b015","title":"Abstract B015: 3D Organoid-Based Therapeutics with Translational Potential in Cancer Immunity and Autoimmune Risk Prediction","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer; Cancer immunotherapy; Organoid; Immunotherapy; Immune checkpoint; Immune system; Immunity; Precision medicine; Ipilimumab","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002586194,0.0003463215,0.0003414911,0.0003243588,0.0001500543,0.0005275518,0.0002429492,0.0004693884,0.004102416],"category_scores_gemma":[0.0002098549,0.0001502665,0.0003363193,0.0001588974,0.0003144886,0.0003147583,0.0003606868,0.0005569211,0.0008655821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004990108,"about_ca_system_score_gemma":0.0003587879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008297149,"about_ca_topic_score_gemma":0.001019268,"domain_scores_codex":[0.999887,0.00003040156,0.000006931157,0.00002186785,0.00003855418,0.00001526064],"domain_scores_gemma":[0.9998934,0.0000334234,0.00002491111,0.00001046628,0.00001650092,0.0000213507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003333114,0.00007001313,0.0003231236,0.0001521191,0.00001613016,0.0001217314,0.00003717458,0.001607195,0.9682716,0.001128177,0.002242386,0.02569704],"study_design_scores_gemma":[0.00009853691,0.001089594,0.003416957,0.0000447768,0.00006024228,0.0008091975,0.00004558593,0.01790013,0.9355876,0.001086458,0.03981607,0.00004490214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6950727,0.03021136,0.2355202,0.003192147,0.001659294,0.0004034166,0.00308751,0.002002159,0.02885127],"genre_scores_gemma":[0.903417,0.005589383,0.07481704,0.0007177142,0.00008642837,0.0001731434,0.0010462,0.000108004,0.01404501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004102416,"threshold_uncertainty_score":0.01372391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02658311133094174,"score_gpt":0.3151417277661127,"score_spread":0.2885586164351709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}