{"id":"W4414493406","doi":"10.1093/database/baaf053","title":"p53motifDB: integration of genomic information and tumour suppressor p53 binding motifs","year":2025,"lang":"en","type":"article","venue":"Database","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University at Albany; National Institutes of Health; Canadian Centre for Applied Research in Cancer Control","keywords":"Suppressor; Chromatin; Gene; Transcription factor; Genome; DNA; DNA binding site; Human genome; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657281,0.00008562443,0.000149082,0.0002666348,0.00003487609,0.00001582461,0.00004860781,0.00005002419,0.00004590478],"category_scores_gemma":[0.0001988914,0.00008113281,0.00003033181,0.000167673,0.0000376229,0.0002663244,0.00007294907,0.0001383011,0.00002918413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007059606,"about_ca_system_score_gemma":0.0001070346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001442263,"about_ca_topic_score_gemma":0.00002520999,"domain_scores_codex":[0.9993895,0.00002020251,0.0002587537,0.0001134975,0.0001126614,0.0001053963],"domain_scores_gemma":[0.9995173,0.00002610264,0.000086897,0.0002505827,0.00006994996,0.00004918728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126088,0.00003333646,0.0004958755,0.0002390929,0.00003618709,0.000006165756,0.0002617501,0.00001606548,0.9853722,0.001157385,0.004359176,0.007910114],"study_design_scores_gemma":[0.003406121,0.0001409258,0.02185921,0.0008736363,0.0002381686,0.00005063942,0.0005117857,0.008840218,0.9463106,0.00005667614,0.01753452,0.0001774946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820479,0.0002596329,0.01481298,0.0003411165,0.0001903256,0.000358423,0.0006208896,0.0000381251,0.001330637],"genre_scores_gemma":[0.9950694,0.00009460593,0.002174847,0.0001977126,0.00002170203,0.00001177334,0.00231374,0.000007462882,0.0001086833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03906164,"threshold_uncertainty_score":0.33085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186119586456941,"score_gpt":0.2605337110777503,"score_spread":0.2486725152131809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}