{"id":"W4414493406","doi":"10.1093/database/baaf053","title":"p53motifDB: integration of genomic information and tumour suppressor p53 binding motifs","year":2025,"lang":"en","type":"article","venue":"Database","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University at Albany; National Institutes of Health; Canadian Centre for Applied Research in Cancer Control","keywords":"Suppressor; Chromatin; Gene; Transcription factor; Genome; DNA; DNA binding site; Human genome; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005587461,0.001219786,0.0009578992,0.003851974,0.0005159793,0.001342207,0.00176046,0.0008524132,0.0220709],"category_scores_gemma":[0.00168119,0.0004416073,0.0004905339,0.003878229,0.0002082761,0.001282636,0.001750433,0.0007116357,0.01424554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004566236,"about_ca_system_score_gemma":0.001063486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003653377,"about_ca_topic_score_gemma":0.004210511,"domain_scores_codex":[0.9997405,0.00003188239,0.00004102394,0.000076302,0.00007254029,0.00003766134],"domain_scores_gemma":[0.9995421,0.00009989321,0.00007200941,0.00007310908,0.00007857587,0.0001344731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00387656,0.0004215029,0.01724394,0.005278298,0.0003411263,0.001645971,0.0006514924,0.003012079,0.06373846,0.01043716,0.5903411,0.3030123],"study_design_scores_gemma":[0.0005148783,0.0003573904,0.02981469,0.0005008005,0.0002613542,0.002481469,0.0004688695,0.01143513,0.04120268,0.0102356,0.902555,0.0001721759],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"software","genre_scores_codex":[0.03300132,0.004082967,0.03843134,0.0005430062,0.0001625314,0.0003426773,0.8454387,0.0610527,0.01694484],"genre_scores_gemma":[0.03954055,0.001766457,0.02730626,0.0002247593,0.00005422053,0.0002218791,0.9249068,0.00220195,0.003777074],"genre_candidate":"software","genre_consensus":null,"teacher_disagreement_score":0.0220709,"threshold_uncertainty_score":0.07383454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186119586456941,"score_gpt":0.2605337110777503,"score_spread":0.2486725152131809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}