{"id":"W4414497631","doi":"10.1016/j.xcrm.2025.102369","title":"Chimeric hemagglutinin-based universal influenza mRNA vaccine induces protective immunity and bone marrow plasma cells in rhesus macaques","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Antibody; Virus; Vaccination; Humoral immunity; Immunity; Immune system; Hemagglutinin (influenza); Bone marrow; Heterologous","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008393766,0.0002653433,0.000543866,0.000567419,0.0001748866,0.000008634007,0.0001097258,0.0002970624,0.000223873],"category_scores_gemma":[0.0005558191,0.000222779,0.00004727206,0.0004636947,0.000258743,0.00008811535,0.0000875874,0.0005976472,0.00001580887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001005225,"about_ca_system_score_gemma":0.0002562898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009693062,"about_ca_topic_score_gemma":0.00003932778,"domain_scores_codex":[0.9981292,0.0003533329,0.0007422975,0.0003738371,0.00006300725,0.0003383452],"domain_scores_gemma":[0.9986923,0.0003003809,0.0004339295,0.0004066202,0.0001367585,0.00002999278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009131288,0.0001175547,0.003795187,0.0001212421,0.00006889906,0.000237183,0.0008292508,0.00001980688,0.9873336,0.00004105293,0.001385979,0.005137099],"study_design_scores_gemma":[0.003804445,0.0003556333,0.03040508,0.0004489406,0.00008631404,0.00009120521,0.001231075,0.00002990866,0.9359011,0.0001391247,0.02728212,0.0002250252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861864,0.004958536,0.00003927542,0.0005221111,0.0007804594,0.0006506848,0.000001604548,0.00007430475,0.006786552],"genre_scores_gemma":[0.9973587,0.0001610183,0.00003746089,0.000249749,0.00002957084,0.00003471792,0.00005479614,0.0000148729,0.002059079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05143249,"threshold_uncertainty_score":0.9084665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008085361678629133,"score_gpt":0.2368779293157439,"score_spread":0.2287925676371147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}