{"id":"W4414498235","doi":"10.1101/2025.09.24.25336431","title":"The Stress-Pain Connection in Chronic Primary Pain: A Systematic Review and Meta-Analysis of Physiological Stress Markers in Relation to Experimental Pain Responses","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vlaamse regering; Fonds Wetenschappelijk Onderzoek","keywords":"Chronic pain; Heart rate variability; Heart rate; Autonomic nervous system; Blood pressure; Chronic stress; Sympathetic activity","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.015394,0.002275461,0.01597399,0.005215777,0.0007395634,0.003256501,0.001927938,0.002014131,0.003200779],"category_scores_gemma":[0.03551472,0.001223554,0.02646473,0.006188352,0.0009505878,0.001487353,0.001553602,0.0014595,0.0002416052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002293409,"about_ca_system_score_gemma":0.004092428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005493788,"about_ca_topic_score_gemma":0.01196528,"domain_scores_codex":[0.9887204,0.00540305,0.003290084,0.001018751,0.001239015,0.0003287979],"domain_scores_gemma":[0.9705837,0.02210899,0.004622755,0.0008310736,0.001615136,0.0002383519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00128223,0.00003260659,0.005221378,0.6242126,0.3580289,0.000121698,0.0001077253,0.0002765103,0.0002374239,0.0001399204,0.0003497568,0.009989285],"study_design_scores_gemma":[0.0004890313,0.0003120137,0.00806141,0.06410412,0.9247135,0.0001311442,0.00007969551,0.0001486841,0.0001445485,0.0002060091,0.001583403,0.00002630589],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.004766379,0.9938684,0.0003497009,0.0001278652,0.00009356744,0.0003078539,0.0003261719,0.00001199753,0.0001482241],"genre_scores_gemma":[0.2083581,0.7856677,0.002060981,0.0008070609,0.0002717563,0.001771315,0.0007993451,0.00002154432,0.0002422252],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01597399,"threshold_uncertainty_score":0.08141226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05360651410735785,"score_gpt":0.3339558715037355,"score_spread":0.2803493573963777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}