{"id":"W4414501637","doi":"10.1158/1538-7445.pediatric25-a019","title":"Abstract A019: Precision radiotherapy for incurable brain tumors: Phase 1b dose & regimen optimization study of iopofosine I 131 in inoperable relapsed or refractory pediatric high-grade glioma, interim data assessment","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Ependymoma; Regimen; Radiation therapy; Refractory (planetary science); Glioma; Dosing; Lesion; Mallinckrodt; Oligodendroglioma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001394469,0.00102713,0.001292251,0.000352483,0.0003424945,0.001234265,0.001055867,0.001057482,0.008116685],"category_scores_gemma":[0.0008009414,0.0004371417,0.0009597561,0.0003944088,0.0005010076,0.0007225169,0.0002808732,0.002847899,0.001480371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009347934,"about_ca_system_score_gemma":0.002402525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001773956,"about_ca_topic_score_gemma":0.004756114,"domain_scores_codex":[0.9996809,0.0001450907,0.00001567435,0.0000474299,0.00004869276,0.00006219472],"domain_scores_gemma":[0.9995541,0.00006870967,0.0001175534,0.00003759547,0.00004197343,0.0001799937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5063632,0.06609527,0.01290716,0.002382882,0.002990446,0.0005896987,0.0006297649,0.009011125,0.09544885,0.001628771,0.05044761,0.2515053],"study_design_scores_gemma":[0.4515562,0.4904037,0.02013841,0.0001978716,0.0008300807,0.0005866936,0.0001690422,0.003209192,0.01102564,0.0009178351,0.0209103,0.00005511805],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9635297,0.00332348,0.002183557,0.001226021,0.0001935743,0.008555833,0.01012996,0.0005359677,0.01032189],"genre_scores_gemma":[0.9359342,0.00539097,0.007666232,0.003004153,0.0001833853,0.0116005,0.01801305,0.0002509387,0.01795653],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.008116685,"threshold_uncertainty_score":0.02715302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1472733964558203,"score_gpt":0.5058630963695415,"score_spread":0.3585896999137212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}