{"id":"W4414501656","doi":"10.1158/1538-7445.pediatric25-a017-pr013","title":"Abstract A017-PR013: Alectinib in children and adolescents with solid or CNS tumors harboring ALK-fusions: An update from the iMATRIX alectinib phase I/II open-label, multi-center study","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Alectinib; Anaplastic lymphoma kinase; Phases of clinical research; Pleomorphic xanthoastrocytoma; Lymphoma; Hematopathology; Crizotinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002922941,0.000342577,0.001080133,0.0003791929,0.0001296103,0.0008482958,0.0005174717,0.0004709398,0.001426343],"category_scores_gemma":[0.001706555,0.0001535372,0.0008246967,0.0007378869,0.0002018123,0.0004703025,0.0002743356,0.0009988914,0.0004857872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003436294,"about_ca_system_score_gemma":0.0008449837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006069037,"about_ca_topic_score_gemma":0.001630247,"domain_scores_codex":[0.9993782,0.0002882352,0.0001058122,0.00005230195,0.0001384231,0.00003704338],"domain_scores_gemma":[0.9981356,0.0006396137,0.0005081219,0.00007414781,0.0004294411,0.0002131525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04343472,0.001354799,0.1218404,0.005609246,0.002998567,0.001285249,0.0002794306,0.0006605074,0.0248727,0.0004508407,0.03026442,0.7669492],"study_design_scores_gemma":[0.05942636,0.07272485,0.5626692,0.004358656,0.01249817,0.01142349,0.0005073985,0.002075766,0.01439415,0.0005148661,0.2592468,0.0001603497],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.7243224,0.2458944,0.002087309,0.005468619,0.00060689,0.001087996,0.007924819,0.0001850744,0.01242245],"genre_scores_gemma":[0.8466676,0.1243145,0.005360433,0.0048478,0.001318506,0.0009167593,0.01400966,0.00009018918,0.002474485],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002922941,"threshold_uncertainty_score":0.01545817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09833172118076185,"score_gpt":0.5130758411045395,"score_spread":0.4147441199237777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}