{"id":"W4414502449","doi":"10.1158/1538-7445.pediatric25-b019","title":"Abstract B019: O-mannosylation represents a therapeutic opportunity in BRAF fusion protein oncogenesis","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Carcinogenesis; Fusion protein; Fusion gene; Gene silencing; MAPK/ERK pathway; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386745,0.0003279461,0.000198532,0.0002264098,0.0001915741,0.0004331556,0.0002168075,0.0004924867,0.002410884],"category_scores_gemma":[0.0001100862,0.0001146479,0.0002335693,0.0001438265,0.0002056628,0.0002157107,0.0002735112,0.0007969418,0.0006960114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003471621,"about_ca_system_score_gemma":0.0002246073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004745916,"about_ca_topic_score_gemma":0.0006427241,"domain_scores_codex":[0.9998957,0.00001285033,0.000007836179,0.00001957718,0.0000383874,0.00002566247],"domain_scores_gemma":[0.9999493,0.000006758665,0.0000143929,0.000005666724,0.000006479296,0.00001736319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009443863,0.00003636142,0.00009072483,0.00003151753,0.000004650583,0.00008310378,0.000006542131,0.00009050577,0.9969213,0.0003464151,0.0001394787,0.002154951],"study_design_scores_gemma":[0.00001693547,0.0003669116,0.0006798959,0.000007032712,0.0000154232,0.0006260684,0.00001596606,0.000419537,0.9894538,0.0001494843,0.008243726,0.000005211754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972539,0.004538261,0.01092172,0.000664301,0.0001463332,0.000131966,0.000890758,0.0005013379,0.009666358],"genre_scores_gemma":[0.9913281,0.001285587,0.003454362,0.0000913964,0.000009600616,0.00003478133,0.000420293,0.00003915981,0.00333676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002410884,"threshold_uncertainty_score":0.008065224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0879244846316891,"score_gpt":0.446756095879901,"score_spread":0.3588316112482119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}