{"id":"W4414513611","doi":"10.1038/s41531-025-01078-w","title":"Genome-wide association study of REM sleep behavior disorder in Parkinson’s disease","year":2025,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"NIHR Oxford Biomedical Research Centre; Fonds de Recherche du Québec - Santé; Otsuka Pharmaceutical Development and Commercialization; National Institutes of Health; Canada First Research Excellence Fund; Agentúra na Podporu Výskumu a Vývoja; University of Oxford; Parkinson's UK; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Verily Life Sciences; Consortium canadien en neurodégénérescence associée au vieillissement; McGill University; Pfizer; NHS Greater Glasgow and Clyde; Celgene; Aligning Science Across Parkinson’s; Sanofi; Michael J. Fox Foundation for Parkinson's Research; Foundation for the National Institutes of Health","keywords":"REM sleep behavior disorder; Linkage disequilibrium; Disease; Parkinson's disease; Genetic association; Association (psychology); Neurology; Attention deficit hyperactivity disorder; Genetic model","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009826224,0.0003730626,0.0004936833,0.0008338204,0.0005020184,0.0006245992,0.0003894448,0.0008031673,0.002146619],"category_scores_gemma":[0.002304354,0.0002328904,0.001017085,0.001595156,0.0002339288,0.000233663,0.0004945238,0.0008237416,0.0002288359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001985684,"about_ca_system_score_gemma":0.000237124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006292278,"about_ca_topic_score_gemma":0.007638373,"domain_scores_codex":[0.999051,0.0003231052,0.0001024981,0.0003615827,0.00009135251,0.00007035699],"domain_scores_gemma":[0.9989359,0.0003519988,0.0003013865,0.0001107849,0.0001380444,0.000161977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008982586,0.00005233785,0.9884376,0.00006442235,0.002732475,0.0004455742,0.0001048847,0.0001399385,0.002899473,0.000118786,0.0006073292,0.003499019],"study_design_scores_gemma":[0.0000428129,0.00006384198,0.9982925,0.000010384,0.0004533298,0.0003238816,0.00004029651,0.0001933615,0.00008925248,0.00007511584,0.0004106011,0.000004561995],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942674,0.002892862,0.0004045412,0.000257222,0.00006060267,0.00001187068,0.001181708,0.00002192768,0.0009019892],"genre_scores_gemma":[0.9979972,0.0004395654,0.0002914727,0.00008148281,0.0000285817,0.00001009936,0.0008027001,0.000008829338,0.0003399994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006292278,"threshold_uncertainty_score":0.01251131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01345277609125841,"score_gpt":0.2796858415106104,"score_spread":0.266233065419352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}