{"id":"W4414518974","doi":"10.1016/j.eururo.2025.08.019","title":"A Multicenter Randomized Controlled Trial of Antimicrobial Prophylaxis to Prevent Urinary Tract Infections after Shockwave Lithotripsy for Urolithiasis: The APPEAL Trial","year":2025,"lang":"en","type":"article","venue":"European Urology","topic":"Kidney Stones and Urolithiasis Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; McMaster University","funders":"Sigrid Juséliuksen Säätiö; Academy of Finland; Physicians' Services Incorporated Foundation; Lawson Health Research Institute; Helsingin ja Uudenmaan Sairaanhoitopiiri","keywords":"Randomized controlled trial; Absolute risk reduction; Antibiotic prophylaxis; Urinary system; Antimicrobial; Ciprofloxacin; Reduction (mathematics); Multicenter trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007649344,0.001621081,0.003976028,0.000549353,0.0006167993,0.001551104,0.0009819873,0.002748745,0.006396868],"category_scores_gemma":[0.01155009,0.0006052966,0.002627625,0.000471508,0.001763541,0.001457673,0.0009363577,0.002656011,0.0006319432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006450898,"about_ca_system_score_gemma":0.001386878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008079612,"about_ca_topic_score_gemma":0.001135043,"domain_scores_codex":[0.9944428,0.004318247,0.0002955574,0.000476636,0.0002524991,0.0002143189],"domain_scores_gemma":[0.9947782,0.002111994,0.00142694,0.0004437111,0.0003963546,0.0008429136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9897059,0.001522753,0.0008476506,0.0009119792,0.001796296,0.00002907829,0.00004409377,0.0001447285,0.0005033081,0.0001631712,0.0005476386,0.003783343],"study_design_scores_gemma":[0.9783859,0.01877644,0.001019886,0.00006183649,0.0009716424,0.00001759386,0.00001563029,0.0002340775,0.00006354455,0.0001704466,0.0002747333,0.000008234038],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722897,0.01268843,0.001284075,0.002569329,0.001950085,0.006028275,0.0009841395,0.0001379992,0.002068052],"genre_scores_gemma":[0.9833601,0.002603843,0.002427273,0.002226265,0.001295299,0.005713801,0.0009340965,0.00002033825,0.001419016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007649344,"threshold_uncertainty_score":0.04045409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009960370916408707,"score_gpt":0.2857452212363404,"score_spread":0.2757848503199317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}