{"id":"W4414519481","doi":"10.1038/s41380-025-03271-y","title":"Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group","year":2025,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Suicide and Self-Harm Studies","field":"Psychology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University Health Network; University of Toronto; Dalhousie University; Montreal Neurological Institute and Hospital; Hospital for Sick Children; Centre for Addiction and Mental Health","funders":"Los Alamos National Laboratory; Argonne National Laboratory; Department of Pathology, University of Utah; Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; National Institute of Environmental Health Sciences; National Cancer Institute; National Institute of Mental Health; Faculty of Medicine and Health, University of Sydney; Erasmus Universitair Medisch Centrum Rotterdam; Medical Research Council; VISN 4 Mental Illness Research, Education, and Clinical Center; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Gentofte Hospital; King's College London; School of Medicine, Emory University; Université de Paris; U.S. Department of Health and Human Services; Utah Department of Health; Berlin Institute of Health; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; McGill University; Universitat Autònoma de Barcelona; Westfälische Wilhelms-Universität Münster; Rheinische Friedrich-Wilhelms-Universität Bonn; Montreal Neurological Institute and Hospital; Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey; Tartu Ülikool; Aarhus Universitetshospital; Freie Universität Berlin; Centre Hospitalier Universitaire Vaudois; Centre d'Imagerie BioMédicale; Institut National de la Santé et de la Recherche Médicale; Humboldt-Universität zu Berlin; H. Lundbeck A/S; Hospital for Sick Children; Università di Bologna; Medizinische Universität Wien; University of California, Los Angeles; National Taiwan University Hospital; Virginia Commonwealth University; Universidade de Coimbra; University of North Carolina at Chapel Hill; Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre; Queensland University of Technology; Universitair Medisch Centrum Utrecht; University of Toronto; NIHR Maudsley Biomedical Research Centre; Dalhousie University; Ludwig-Maximilians-Universität München; Radboud Universiteit; State University of New York Upstate Medical University; Curtin University of Technology; State University of New York; National Taiwan University; GGZ inGeest; Universität Heidelberg; Trinity College Dublin; King Abdullah University of Science and Technology; University of Oxford; QIMR Berghofer Medical Research Institute; Karolinska Institutet; Amsterdam University Medical Centers; Cardiff University; Syracuse University; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Broad Institute; U.S. Department of Veterans Affairs; NorthShore University HealthSystem; Perelman School of Medicine, University of Pennsylvania; Universitätsmedizin Göttingen; Amsterdam Neuroscience; NIH Clinical Center; Universidad de Granada; University of Texas Health Science Center at Houston; South London and Maudsley NHS Foundation Trust; Norges Teknisk-Naturvitenskapelige Universitet; Radboud Universitair Medisch Centrum; University of New South Wales; University of Pittsburgh; Queensland Brain Institute; National Health Research Institutes; University of California, San Diego; Lundbeckfonden; Universitetet i Oslo; Johns Hopkins University; Instituto de Investigación Sanitaria Fundación Jiménez Díaz; Universität Basel; Aarhus Universitet; University of Pennsylvania; Philipps-Universität Marburg; Children's Hospital of Philadelphia; Saint Petersburg State University; Kaiser Permanente; University of Minnesota; David Geffen School of Medicine, University of California, Los Angeles; Université de Lausanne; National Science Foundation; Universität Wien; Regeneron Pharmaceuticals; Health Services Research and Development; Harvard T.H. Chan School of Public Health; National Institute for Health and Care Research; University of Queensland; Emory University; Universitat de Barcelona; Division of Cancer Epidemiology and Genetics, National Cancer Institute; St. Edmund Hall, University of Oxford; Centre National de la Recherche Scientifique; SUNY Downstate Medical Center; University College London; University of Southern California","keywords":"Suicidal ideation; Genome-wide association study; Genomics; Poison control; Psychiatric genetics; Association (psychology); Human factors and ergonomics; Suicide prevention","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03267952,0.001233242,0.004264234,0.006193548,0.000724289,0.003935933,0.003535201,0.003212664,0.001244988],"category_scores_gemma":[0.02924045,0.0006450883,0.002514936,0.005022219,0.002481315,0.004344879,0.002942027,0.009517229,0.0007250271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003352822,"about_ca_system_score_gemma":0.01059027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004856159,"about_ca_topic_score_gemma":0.006950941,"domain_scores_codex":[0.9932127,0.003024558,0.001889711,0.0005046865,0.001193279,0.0001751347],"domain_scores_gemma":[0.9688186,0.0209224,0.001438473,0.000763609,0.007377625,0.0006792612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001305609,0.00004885036,0.000948792,0.04210955,0.0006379902,0.0002169181,0.0005621455,0.0004525766,0.0006145646,0.02774191,0.042847,0.8836891],"study_design_scores_gemma":[0.0001222787,0.0001354331,0.003778518,0.09422986,0.001191921,0.001622912,0.0006261557,0.0003638757,0.0003903694,0.02716603,0.870259,0.0001135549],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001089788,0.9901419,0.0009032951,0.007631223,0.00058578,0.00004179565,0.00003487761,0.000009856341,0.0005422684],"genre_scores_gemma":[0.001265961,0.9897279,0.004111235,0.003809183,0.0005707745,0.0001241875,0.0001309834,0.00001035586,0.0002493929],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03267952,"threshold_uncertainty_score":0.1728278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04146686803922419,"score_gpt":0.3646002166166139,"score_spread":0.3231333485773897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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