{"id":"W4414524388","doi":"10.1021/jacs.5c10056","title":"DNA-Templated Assembly of Metalloprotein Mimics with Hydrolytic Activity","year":2025,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Metalloprotein; Trimer; Peptide; Enzyme; Covalent bond; Folding (DSP implementation); Peptide sequence; Hydrolysis; Protein structure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002016802,0.0001304254,0.0004028453,0.00001328411,0.00003914599,0.00001096202,0.0003854616,0.00007382005,0.000004889049],"category_scores_gemma":[0.0001335112,0.00007643284,0.0007022471,0.0003818328,0.0003374713,0.000004270173,0.0001296721,0.0002059517,1.941256e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004347616,"about_ca_system_score_gemma":0.0001126005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003036783,"about_ca_topic_score_gemma":0.000001832079,"domain_scores_codex":[0.9991403,0.00004536852,0.0002837262,0.0001509927,0.0002242359,0.0001553727],"domain_scores_gemma":[0.998866,0.00004705229,0.0006273102,0.000263549,0.0001391735,0.00005692557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001608764,0.000122568,0.001044473,0.00001655551,0.0006997432,3.89667e-7,0.000009697264,0.00002618622,0.9956163,0.000002893787,0.0009482577,0.00135204],"study_design_scores_gemma":[0.0002976767,0.00008180681,0.0008725058,0.00004448466,0.0002442437,0.0000101398,0.00004992805,0.0001190433,0.9969133,0.00003339702,0.001243662,0.00008981042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99788,0.0001127873,0.0007315413,0.001055036,0.0000177009,0.00004821541,0.000004076418,0.000002370583,0.0001482772],"genre_scores_gemma":[0.9980624,0.0000774276,0.001315415,0.0003483352,0.00006179632,0.000001639529,0.000001271704,0.000009457878,0.0001222647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296984,"threshold_uncertainty_score":0.3116841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005088775274866071,"score_gpt":0.2358460654685489,"score_spread":0.2307572901936828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}