{"id":"W4414524388","doi":"10.1021/jacs.5c10056","title":"DNA-Templated Assembly of Metalloprotein Mimics with Hydrolytic Activity","year":2025,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Metalloprotein; Trimer; Peptide; Enzyme; Covalent bond; Folding (DSP implementation); Peptide sequence; Hydrolysis; Protein structure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705913,0.0002796079,0.0002736149,0.0001510984,0.00009638572,0.0002997815,0.0002858862,0.000384813,0.0005647546],"category_scores_gemma":[0.0003782631,0.0001829879,0.0002425504,0.0001663005,0.0001615359,0.0002187149,0.0002689886,0.0003944195,0.0003583634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003799937,"about_ca_system_score_gemma":0.0001812369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002525607,"about_ca_topic_score_gemma":0.0005437445,"domain_scores_codex":[0.9998312,0.00002826418,0.00001415149,0.00004731405,0.0000526181,0.00002642161],"domain_scores_gemma":[0.9998448,0.00002755813,0.00004712597,0.00001705636,0.00002269208,0.00004079031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004527521,0.00002720642,0.0001158586,0.00003490299,0.00000786058,0.00006755123,0.00001919915,0.0008187098,0.9967615,0.0002063802,0.00003703536,0.001858665],"study_design_scores_gemma":[0.00001222524,0.0002534568,0.0003428708,0.000003177145,0.000008606949,0.0001185503,0.000009101784,0.003930711,0.9935496,0.00004217144,0.001722896,0.000006596786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827495,0.000910058,0.01349978,0.00007816203,0.00004932637,0.00009530348,0.0001638063,0.0002151504,0.002239078],"genre_scores_gemma":[0.9801777,0.0003662547,0.01715899,0.00004297297,0.000007649834,0.00005674829,0.000204915,0.00003033583,0.00195442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005647546,"threshold_uncertainty_score":0.002757072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005088775274866071,"score_gpt":0.2358460654685489,"score_spread":0.2307572901936828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}