{"id":"W4414530922","doi":"10.1172/jci.insight.199235","title":"CD4+ and CD8+ T cells are not the main driver of Lassa fever pathogenesis in macaques","year":2025,"lang":"en","type":"article","venue":"JCI Insight","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Canadian Institutes of Health Research; Public Health Agency of Canada; Coalition for Epidemic Preparedness Innovations; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Lassa fever; Lassa virus; Arenavirus; Pathogenesis; Disease; T cell; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447265,0.0002332255,0.0002437378,0.0003492571,0.0003457113,0.0004025506,0.0001573245,0.0003377697,0.0015018],"category_scores_gemma":[0.0004804689,0.0001396353,0.0001228927,0.00007787727,0.0004434875,0.0003384686,0.0002644523,0.000577161,0.0002273828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919982,"about_ca_system_score_gemma":0.000236486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001292595,"about_ca_topic_score_gemma":0.002188929,"domain_scores_codex":[0.9998228,0.00004058059,0.00001140729,0.00004365245,0.00002653524,0.0000549552],"domain_scores_gemma":[0.9997457,0.00004507672,0.00008032414,0.00003801792,0.00002809255,0.00006279608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006975806,0.0001213774,0.03144929,0.0001485698,0.00003246643,0.0004495294,0.0003742928,0.0001018253,0.9548853,0.0004263263,0.0002516469,0.01106181],"study_design_scores_gemma":[0.00011614,0.003200763,0.6266175,0.0002429717,0.000194822,0.01015718,0.002344255,0.002766814,0.3305462,0.002520563,0.02124658,0.00004624954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961164,0.001587503,0.0005092098,0.0001550248,0.0000152084,0.00001436856,0.0001184894,0.00002505336,0.001458782],"genre_scores_gemma":[0.9973096,0.0006379035,0.0004377732,0.0001527318,0.00002007741,0.00004372815,0.0001683368,0.000007704914,0.001222132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0015018,"threshold_uncertainty_score":0.005024016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956848656244305,"score_gpt":0.2979617334749936,"score_spread":0.2783932469125506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}