{"id":"W4414532372","doi":"10.1158/1538-7445.pediatric25-a016","title":"Abstract A016: ews-nf: A custom workflow for tumor cell annotation and analysis of single-cell RNA-sequencing of paired patient Ewing sarcoma specimens from the Sean Karl cohort","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Sarcoma; Cancer; Metastasis; Fusion gene; Workflow; Cell; CD8; Primary tumor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00492199,0.002097777,0.00121945,0.002495097,0.001672127,0.002603039,0.001794608,0.0009502812,0.04765092],"category_scores_gemma":[0.005297647,0.00133468,0.00191275,0.001052887,0.0007879332,0.0009406911,0.002257271,0.002236396,0.03241353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00123865,"about_ca_system_score_gemma":0.002420983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003496469,"about_ca_topic_score_gemma":0.006325357,"domain_scores_codex":[0.997602,0.0002256006,0.0002653975,0.001161194,0.0005491328,0.0001965366],"domain_scores_gemma":[0.9972848,0.0007770361,0.0001984881,0.000785679,0.0006163421,0.0003376387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005993466,0.0004216126,0.03352756,0.001884406,0.0006392439,0.001256197,0.002289542,0.0079632,0.4465852,0.00649767,0.2961986,0.1967432],"study_design_scores_gemma":[0.001225645,0.0007615248,0.07281625,0.0004785964,0.0002765399,0.001352477,0.000699544,0.1030456,0.3634139,0.02062219,0.4345994,0.0007084085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.04039305,0.0005389855,0.4388911,0.0006224246,0.0007399734,0.002675388,0.1910618,0.3127794,0.01229787],"genre_scores_gemma":[0.08273099,0.0003746106,0.6248541,0.001159381,0.0002624709,0.008785393,0.2211623,0.04479629,0.01587445],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04765092,"threshold_uncertainty_score":0.1594082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07708239893147757,"score_gpt":0.3514342762609594,"score_spread":0.2743518773294819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}