{"id":"W4414533290","doi":"10.1016/j.gene.2025.149774","title":"Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications","year":2025,"lang":"en","type":"article","venue":"Gene","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Congressionally Directed Medical Research Programs; Fonds de Recherche du Québec - Santé; Associazione Italiana per la Ricerca sul Cancro; Canadian Institutes of Health Research; Generalitat de Catalunya; Fundación Científica Asociación Española Contra el Cáncer; Fundación Cellex; U.S. Department of Defense; McGill University; Faculty of Medicine, McGill University; Prostate Cancer Foundation; Agencia Estatal de Investigación","keywords":"Prostate cancer; Senescence; Disease; Mechanism (biology); Prostate; Cancer; Phenotype; Translational research; Adverse effect; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017057,0.0006208878,0.001244393,0.001119633,0.0003934788,0.001490555,0.0006688305,0.001133543,0.00298644],"category_scores_gemma":[0.001228818,0.0002109416,0.0009040896,0.0008267286,0.0007554096,0.001561637,0.0008217825,0.002956851,0.0008353621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007891171,"about_ca_system_score_gemma":0.001672757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006351456,"about_ca_topic_score_gemma":0.00180787,"domain_scores_codex":[0.9996489,0.0001096616,0.00003931052,0.00005268562,0.00009642571,0.00005301621],"domain_scores_gemma":[0.9993055,0.0003264133,0.00007909393,0.0000245327,0.0001830103,0.00008142927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005093516,0.0003260544,0.001029104,0.02304276,0.0001708639,0.0004761962,0.0002537817,0.0009915812,0.009677758,0.01551859,0.02902505,0.9189789],"study_design_scores_gemma":[0.0001373979,0.001870262,0.003328834,0.008424598,0.0004438892,0.003444258,0.0003400719,0.0009201735,0.00467894,0.01346559,0.962862,0.0000839397],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006050341,0.9962754,0.0003790755,0.001522878,0.0002732523,0.00001279235,0.00002635731,0.00001641997,0.0008887498],"genre_scores_gemma":[0.005579722,0.991787,0.0005426625,0.000891543,0.0006439328,0.0000320108,0.00006596449,0.000005544222,0.0004515241],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00298644,"threshold_uncertainty_score":0.009990633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05094674532917338,"score_gpt":0.3739027707487815,"score_spread":0.3229560254196081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}