{"id":"W4414535538","doi":"10.1126/sciimmunol.adv6870","title":"Inhibitory immune checkpoints in cancer immunotherapy","year":2025,"lang":"en","type":"review","venue":"Science Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Immune system; Monoclonal antibody; Cancer immunotherapy; Immunotherapy; Inhibitory postsynaptic potential; Cancer; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005351183,0.0008149438,0.000953094,0.001538544,0.0002392779,0.0009328809,0.0007053515,0.0009794566,0.003244725],"category_scores_gemma":[0.0003988411,0.0002229784,0.0004160326,0.001166601,0.0005177747,0.001234634,0.0007725323,0.002584449,0.002116566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006392941,"about_ca_system_score_gemma":0.0007307178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004754193,"about_ca_topic_score_gemma":0.0008766505,"domain_scores_codex":[0.999833,0.00003183745,0.00001467061,0.00002259817,0.00007363619,0.00002419754],"domain_scores_gemma":[0.999873,0.00005534786,0.00001907594,0.000004924123,0.00003144943,0.0000160746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000713586,0.00008887635,0.0001086657,0.01164867,0.00005664959,0.0001638958,0.00007008458,0.0005744621,0.004827372,0.0123792,0.03274297,0.9372678],"study_design_scores_gemma":[0.00001296517,0.00007495243,0.0002526296,0.001855303,0.00003251003,0.0005599678,0.00002877928,0.00008356862,0.0006762689,0.003772537,0.9926406,0.000009977431],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001333632,0.9975629,0.0002238121,0.0003103277,0.0003425562,0.000006544644,0.00001101309,0.00001054138,0.001398998],"genre_scores_gemma":[0.001089144,0.9969536,0.0002216187,0.0002870871,0.0002602188,0.0000101415,0.00002281047,0.000001840337,0.001153603],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003244725,"threshold_uncertainty_score":0.01085472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0346951688554065,"score_gpt":0.3908465688880493,"score_spread":0.3561514000326427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}