{"id":"W4414535538","doi":"10.1126/sciimmunol.adv6870","title":"Inhibitory immune checkpoints in cancer immunotherapy","year":2025,"lang":"en","type":"review","venue":"Science Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Immune system; Monoclonal antibody; Cancer immunotherapy; Immunotherapy; Inhibitory postsynaptic potential; Cancer; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001328402,0.0006113974,0.002548176,0.002133682,0.0001717546,0.00005586677,0.001079474,0.0006301252,0.0003939603],"category_scores_gemma":[0.0001590237,0.000488154,0.0007070807,0.004111013,0.002264732,0.0002035161,0.0002704707,0.001111064,0.0000602379],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001883799,"about_ca_system_score_gemma":0.008412918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108545,"about_ca_topic_score_gemma":0.0000664984,"domain_scores_codex":[0.9960787,0.0001723691,0.001310454,0.001026043,0.0004261468,0.0009862774],"domain_scores_gemma":[0.9979259,0.0001598243,0.0004670268,0.001217067,0.0001575318,0.00007258375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002516115,0.0001573305,0.00002664386,0.003388881,0.0002398524,0.00003522626,0.0001137758,7.587901e-8,0.003037936,0.00006496152,0.0001317048,0.992552],"study_design_scores_gemma":[0.001777482,0.0002232046,0.0008558905,0.02971601,0.0001736177,0.0001581639,0.00006109964,0.000001007707,0.0004660084,0.00003361616,0.9660698,0.0004641069],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002788341,0.9923725,0.000002937724,0.0003035061,0.003069172,0.001438308,0.00001527453,0.0001429556,0.002376519],"genre_scores_gemma":[0.00008155197,0.995688,0.00008550729,0.0002881345,0.0001252845,0.0005264701,0.00002229378,0.00006898112,0.003113822],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9920879,"threshold_uncertainty_score":0.999757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0346951688554065,"score_gpt":0.3908465688880493,"score_spread":0.3561514000326427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}