{"id":"W4414540628","doi":"10.12688/hrbopenres.14159.1","title":"Real world use of avacopan for ANCA-associated vasculitis. First experiences in Ireland.","year":2025,"lang":"en","type":"article","venue":"HRB Open Research","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Discontinuation; Granulomatosis with polyangiitis; Vasculitis; Adverse effect; Cohort; Prednisolone; Regimen; Rituximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001156822,0.00009412399,0.000372886,0.0005215576,0.0002429814,0.000103468,0.0003175259,0.0001253481,0.0005166084],"category_scores_gemma":[0.0008026318,0.00007732479,0.0001128213,0.001443225,0.0002023645,0.0001797743,0.0002194989,0.0003832311,0.00001577666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001752438,"about_ca_system_score_gemma":0.0004490114,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007878065,"about_ca_topic_score_gemma":0.008539841,"domain_scores_codex":[0.99831,0.0001658418,0.0003709366,0.0003211281,0.0003878151,0.0004442777],"domain_scores_gemma":[0.9984632,0.0006561102,0.00004372817,0.0003570253,0.0003731557,0.0001068409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.00205895,0.003497703,0.3834254,0.0008996077,0.001393806,0.0003028422,0.01684061,0.0000728272,0.001838559,0.05468038,0.5152611,0.01972822],"study_design_scores_gemma":[0.01852248,0.001036409,0.783483,0.003987141,0.0001283207,0.000007307465,0.009535142,0.001454131,0.003096431,0.002875809,0.1755185,0.0003553682],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9327033,0.0002830454,0.0000132477,0.003998993,0.0001362145,0.002423187,0.00005355501,0.0000226877,0.0603658],"genre_scores_gemma":[0.9480346,0.0006597795,0.0003651581,0.00006290144,0.00002721136,0.0009028274,0.0001155064,0.00001361996,0.0498184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4000576,"threshold_uncertainty_score":0.9987286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1489669515196963,"score_gpt":0.4373944815349133,"score_spread":0.288427530015217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}