{"id":"W4414540873","doi":"10.7554/elife.107121.2.sa4","title":"eLife Assessment: Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Ubiquitin ligase; Ubiquitin; Mutation; Mutant; Ubiquitin-Protein Ligases; Suppressor; Proteasome; HEK 293 cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.000944354,0.0006489946,0.0006766955,0.001231428,0.001549775,0.002738648,0.001289503,0.002216721,0.08760141],"category_scores_gemma":[0.001652282,0.0005331984,0.0003713651,0.0006818177,0.0009527599,0.000954397,0.002506508,0.002052139,0.03291401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001128717,"about_ca_system_score_gemma":0.001718431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001414169,"about_ca_topic_score_gemma":0.003576926,"domain_scores_codex":[0.9990572,0.00006090304,0.00006486354,0.0001653244,0.0004516106,0.0002000477],"domain_scores_gemma":[0.9985021,0.0001495539,0.0002271101,0.00009505881,0.0003144013,0.0007118343],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002955773,0.0003177217,0.01043627,0.001213984,0.0001699352,0.007906349,0.0003932048,0.001281139,0.3299888,0.01095709,0.4627951,0.1715847],"study_design_scores_gemma":[0.0005104092,0.0002794876,0.02268036,0.0002429252,0.00008927382,0.006047469,0.0008857668,0.006712387,0.1424728,0.005990652,0.8140228,0.00006561335],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.3364305,0.02018906,0.07731567,0.09261123,0.02265158,0.0008687696,0.04064623,0.02352582,0.3857611],"genre_scores_gemma":[0.5178853,0.009669921,0.05664239,0.007578653,0.005295387,0.0004097624,0.03167575,0.001736446,0.3691064],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.9990556,"threshold_uncertainty_score":0.2930559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02714906253553349,"score_gpt":0.3381480941294129,"score_spread":0.3109990315938794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}