{"id":"W4414542547","doi":"10.70962/jhi.20250135","title":"Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral hepatitis","year":2025,"lang":"en","type":"article","venue":"Journal of Human Immunity","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institutes of Health; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; National Center for Advancing Translational Sciences; Institut des maladies génétiques Imagine; Institute of Clinical and Translational Sciences; European Molecular Biology Organization; St. Giles Foundation; Rockefeller University; Agence Nationale de la Recherche; Howard Hughes Medical Institute","keywords":"Fulminant; Fulminant hepatitis; Viral hepatitis; Viral disease; Hepatitis; Hepatitis A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009160519,0.0002529978,0.0005488273,0.0008167063,0.0005513919,0.00004860537,0.0006843914,0.0001407333,0.0002392117],"category_scores_gemma":[0.0001040081,0.0002036354,0.0001677702,0.00072399,0.0004625153,0.0003140403,0.0001258858,0.001287288,0.00003089029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001176904,"about_ca_system_score_gemma":0.0002503876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002504275,"about_ca_topic_score_gemma":0.0004831074,"domain_scores_codex":[0.997953,0.0003994036,0.0009117448,0.0001751282,0.00008596374,0.0004747863],"domain_scores_gemma":[0.9987689,0.0001091877,0.0004916419,0.0003800644,0.0002402544,0.000009978557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001079885,0.002295609,0.06144545,0.0001053658,0.00029846,0.0001326269,0.005965277,0.0001876432,0.9041364,0.005220949,0.0004616327,0.01867071],"study_design_scores_gemma":[0.0186543,0.003538556,0.8535317,0.001775776,0.000284991,0.0006955052,0.01056191,0.00002794699,0.08409163,0.003116971,0.02262172,0.001098948],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823456,0.01247366,0.0001142522,0.0001802533,0.000506296,0.0001523164,0.000006548789,0.00002417143,0.004196898],"genre_scores_gemma":[0.9984347,0.0001957502,0.00004655619,0.0001759193,0.000004192505,0.000005001727,0.00001956731,0.00001505969,0.001103248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8200448,"threshold_uncertainty_score":0.8304012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008264570482411467,"score_gpt":0.2709540759332093,"score_spread":0.2626895054507978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}