{"id":"W4414548305","doi":"10.1097/qad.0000000000004261","title":"Off target effects of HIV integrase strand transfer inhibitors in cell and animal models: a scoping review","year":2025,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"B.C. Women's Hospital & Health Centre; Women's Health Research Institute; University of British Columbia; University of British Columbia Hospital","funders":"","keywords":"Integrase; Adverse effect; Lentivirus; Human immunodeficiency virus (HIV); In vivo; Cell; In vitro; Integrase inhibitor; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590829,0.0001356553,0.0004380507,0.0001545178,0.00001667992,0.000004284748,0.00003129102,0.00005037236,0.00002013718],"category_scores_gemma":[0.00002841949,0.0001045993,0.00005948825,0.0002638801,0.00003556904,0.00006544088,0.00001516939,0.000102963,0.000002586812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003218594,"about_ca_system_score_gemma":0.0001394263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001096075,"about_ca_topic_score_gemma":0.000008113947,"domain_scores_codex":[0.9992197,0.00004241694,0.0002938712,0.0001894955,0.0001119428,0.0001425292],"domain_scores_gemma":[0.9997042,0.00008763872,0.00001699795,0.0001079873,0.00002645465,0.00005668482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"systematic_review","study_design_scores_codex":[0.002075189,0.004782564,0.4283246,0.3563372,0.001367399,0.001260291,0.01070994,0.00003164243,0.04181232,0.004567086,0.01243078,0.136301],"study_design_scores_gemma":[0.0237494,0.00141537,0.005936457,0.5037546,0.001664744,0.0000171095,0.000416379,0.001007909,0.4593755,0.0008797395,0.001109266,0.000673598],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.884621,0.108857,0.0006048342,0.0008898483,0.00004731108,0.001434442,0.000003966662,0.00002222919,0.003519356],"genre_scores_gemma":[0.9847817,0.01248577,0.001423737,0.0002002793,0.00000936112,0.00005173406,0.00001595993,0.00000950089,0.001021938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4223881,"threshold_uncertainty_score":0.4265435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008712050014593175,"score_gpt":0.2608097200134455,"score_spread":0.2520976699988524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}