{"id":"W4414548305","doi":"10.1097/qad.0000000000004261","title":"Off target effects of HIV integrase strand transfer inhibitors in cell and animal models: a scoping review","year":2025,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"B.C. Women's Hospital & Health Centre; Women's Health Research Institute; University of British Columbia; University of British Columbia Hospital","funders":"","keywords":"Integrase; Adverse effect; Lentivirus; Human immunodeficiency virus (HIV); In vivo; Cell; In vitro; Integrase inhibitor; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004516355,0.00108302,0.003382869,0.005808703,0.0004366325,0.002226479,0.001264977,0.00179305,0.003136686],"category_scores_gemma":[0.009955646,0.0004707616,0.002703748,0.00487508,0.0006498327,0.001537623,0.0009258792,0.001202072,0.0007472524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001124009,"about_ca_system_score_gemma":0.005105386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00344912,"about_ca_topic_score_gemma":0.006807677,"domain_scores_codex":[0.9982677,0.0004928061,0.0006392681,0.0001154775,0.0004232333,0.00006152834],"domain_scores_gemma":[0.9902551,0.007149169,0.00114209,0.0001398412,0.00122666,0.00008720394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001541913,0.00005794887,0.0002426126,0.4424844,0.001387456,0.0002285183,0.0002709555,0.0003324303,0.001249433,0.001819838,0.008801094,0.5429711],"study_design_scores_gemma":[0.00005206918,0.000337,0.001169645,0.5820005,0.007977756,0.0006366624,0.0003954527,0.000158414,0.001213762,0.001693458,0.4043177,0.00004764649],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001699163,0.9986591,0.00014319,0.00026561,0.0001240668,0.00005481172,0.00006754739,0.000004507789,0.0005112161],"genre_scores_gemma":[0.0008691127,0.9983765,0.0002769295,0.0001768587,0.00004801092,0.00005288131,0.00005710928,0.000001833242,0.0001408126],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005808703,"threshold_uncertainty_score":0.02388501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008712050014593175,"score_gpt":0.2608097200134455,"score_spread":0.2520976699988524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}