{"id":"W4414557720","doi":"10.1016/j.ijrobp.2025.07.1361","title":"Prediction of Severe Early Toxicities with pATM Blood Assay: Results from a Prospective Real-Life Study","year":2025,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alzheimer Society of Canada","funders":"","keywords":"Toxicity; Adverse effect; Common Terminology Criteria for Adverse Events; Clinical endpoint; Cohort; Prospective cohort study; Univariate analysis; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002913852,0.0002364255,0.0009493476,0.0001747404,0.00006854262,0.00003456079,0.0005338226,0.0003009946,0.00003635476],"category_scores_gemma":[0.02936447,0.0001877799,0.0001912465,0.0002696764,0.0002854161,0.0002155182,0.0001045467,0.0006161093,0.000003527765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003708025,"about_ca_system_score_gemma":0.0007207327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001142984,"about_ca_topic_score_gemma":0.0000190583,"domain_scores_codex":[0.995337,0.001576137,0.002028483,0.0003547722,0.0005098419,0.000193774],"domain_scores_gemma":[0.9711166,0.02436374,0.00254043,0.0002737978,0.001606842,0.00009860248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.006062264,0.004537762,0.7682501,0.00002348966,0.006263166,0.00005534471,0.002977299,0.0002530997,0.0008709277,0.1870776,0.001307691,0.02232124],"study_design_scores_gemma":[0.0161321,0.004324563,0.2008369,0.000199504,0.0007939096,0.00001238522,0.0006601791,0.0003585658,0.001447804,0.7749131,0.0001503022,0.0001706617],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.892754,0.00004126916,0.09962669,0.0008280589,0.002389042,0.0006855585,0.001465335,0.00005784181,0.002152205],"genre_scores_gemma":[0.9035022,0.00009948777,0.09475816,0.0001585482,0.001344921,0.00002704227,0.00001990331,0.00002377208,0.00006599128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5878356,"threshold_uncertainty_score":0.9788116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1608472946875225,"score_gpt":0.4635295574020312,"score_spread":0.3026822627145086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}