{"id":"W4414558797","doi":"10.17615/j68m-aa83","title":"Structural Chemistry of Helicase Inhibition","year":2025,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genentech; Ontario Genomics; National Institutes of Health; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Mitacs; Genome Canada; McGill University; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Helicase; RNA Helicase A; DNA; Structural biology; Enzyme; Cocrystal; Translation (biology); ATP hydrolysis; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00002682693,0.0001369639,0.000191536,0.00002051786,0.00007062064,0.00004975088,0.0001294246,0.0001464613,0.003374908],"category_scores_gemma":[0.0001344422,0.0001325722,0.00009737059,0.0001581172,0.0001848075,0.0001773876,0.00009330783,0.0001204857,0.000003718236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002048055,"about_ca_system_score_gemma":0.00009536821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001079665,"about_ca_topic_score_gemma":5.192904e-7,"domain_scores_codex":[0.9992897,0.000005151991,0.0002470924,0.0001993033,0.0001101925,0.0001485616],"domain_scores_gemma":[0.99941,0.0001115511,0.00007792687,0.0003190817,0.00003720829,0.00004421585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005487045,0.0000199399,0.0006170833,0.0006618452,0.00003856312,0.000008525702,0.0001275851,0.000004979159,0.9858509,0.01070484,0.001111967,0.0007989259],"study_design_scores_gemma":[0.0002179293,0.000001431744,0.00003554207,0.000114162,0.00002459014,0.000004727903,0.0003308066,0.00007847767,0.9722921,0.02521415,0.00157191,0.0001141501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8505087,0.0002994849,0.00001530662,0.0002507131,0.00003530634,0.00001680578,0.00005689235,0.00008966285,0.1487271],"genre_scores_gemma":[0.9907162,0.000003178215,0.0004504349,0.0000551971,0.00009210675,0.000008679986,0.00009263343,0.000009546307,0.00857205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1402074,"threshold_uncertainty_score":0.9975361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009685603516869336,"score_gpt":0.2079886917442912,"score_spread":0.1983030882274219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}