{"id":"W4414558797","doi":"10.17615/j68m-aa83","title":"Structural Chemistry of Helicase Inhibition","year":2025,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genentech; Ontario Genomics; National Institutes of Health; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Mitacs; Genome Canada; McGill University; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Helicase; RNA Helicase A; DNA; Structural biology; Enzyme; Cocrystal; Translation (biology); ATP hydrolysis; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497937,0.0003798291,0.0002309995,0.0001338637,0.0003872389,0.0005306579,0.0005419034,0.0003222967,0.005740403],"category_scores_gemma":[0.0002227256,0.0001984198,0.0001501548,0.0001566828,0.0003626741,0.0005275694,0.0003989295,0.001027155,0.001060506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007361721,"about_ca_system_score_gemma":0.0004032914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006994885,"about_ca_topic_score_gemma":0.0006550115,"domain_scores_codex":[0.9998808,0.00001487588,0.000004219417,0.00002696604,0.00003545227,0.00003772983],"domain_scores_gemma":[0.9999601,0.000008464398,0.000007351584,0.000005508419,0.000008770177,0.000009731153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004782912,0.0002891565,0.0004149896,0.001203038,0.00006435552,0.0006760497,0.0002546211,0.0167276,0.6740454,0.2112388,0.0184476,0.07616005],"study_design_scores_gemma":[0.0001717437,0.001019928,0.0005408765,0.0001193822,0.00004250792,0.0006534749,0.0001485303,0.02271728,0.735123,0.02743567,0.2119713,0.00005629753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4845204,0.05516913,0.09497753,0.01044206,0.002607625,0.00036596,0.001578588,0.001627321,0.3487114],"genre_scores_gemma":[0.9574379,0.0174108,0.005853012,0.001304947,0.0001354168,0.0001324619,0.0004804216,0.00008949648,0.01715554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005740403,"threshold_uncertainty_score":0.01920354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009685603516869336,"score_gpt":0.2079886917442912,"score_spread":0.1983030882274219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}