{"id":"W4414559917","doi":"10.1002/mdc3.70376","title":"Reply: “Leigh Syndrome Due to the Variant c. <scp>1019T</scp> &gt;C in <scp>COX15</scp> ”","year":2025,"lang":"en","type":"letter","venue":"Movement Disorders Clinical Practice","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Toronto Western Hospital; Hospital for Sick Children","funders":"","keywords":"Disease; Mutation; MEDLINE; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001894306,0.000892676,0.001183103,0.0007377329,0.003069414,0.002470267,0.00157612,0.04864803,0.006119364],"category_scores_gemma":[0.01363819,0.000842564,0.00104253,0.0006390543,0.002115094,0.002405136,0.001505499,0.02833783,0.005901346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002633457,"about_ca_system_score_gemma":0.002765295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007550231,"about_ca_topic_score_gemma":0.01018601,"domain_scores_codex":[0.9984825,0.0004128554,0.0002030846,0.000237042,0.0003380565,0.0003264865],"domain_scores_gemma":[0.9971427,0.00151527,0.0002549711,0.00009018472,0.0004817433,0.0005150879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001072518,0.00004969092,0.001710204,0.00005150783,0.00003417954,0.008451619,0.0002334601,0.0001035105,0.000312934,0.00187071,0.9823607,0.004714152],"study_design_scores_gemma":[0.0003398423,0.0001956109,0.005198047,0.0006014732,0.0001327871,0.01507909,0.001276989,0.001213996,0.0006696222,0.01656407,0.9585227,0.000205722],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0008105817,0.0007153427,0.0001070316,0.9815176,0.01487281,0.00001329646,0.00009017078,0.00002828032,0.001844845],"genre_scores_gemma":[0.004835936,0.0005249649,0.0002004898,0.9745984,0.01462373,0.00003223676,0.00005092073,0.00002106945,0.00511237],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04864803,"threshold_uncertainty_score":0.02047133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01957577685178671,"score_gpt":0.3089119804420648,"score_spread":0.2893362035902781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}