{"id":"W4414566467","doi":"10.1002/cctc.202500809","title":"Essential Logic and Facts Behind the Expansion of the Genetic Code: A Critical Assessment","year":2025,"lang":"en","type":"article","venue":"ChemCatChem","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Manitoba; Research Manitoba","keywords":"Genetic code; Amino acid; Translation (biology); Flexibility (engineering); Stop codon; Codon usage bias","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01218305,0.001240108,0.001040841,0.004388935,0.002539583,0.006588966,0.001982698,0.003461726,0.003207225],"category_scores_gemma":[0.01325791,0.0005673952,0.0005901207,0.001473071,0.03285845,0.02148566,0.003628411,0.01027153,0.0007295467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005641545,"about_ca_system_score_gemma":0.002900323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001654823,"about_ca_topic_score_gemma":0.001224548,"domain_scores_codex":[0.9971294,0.001310826,0.0001957273,0.0004619814,0.0007190204,0.0001830248],"domain_scores_gemma":[0.9832097,0.01393161,0.0005014027,0.0006956707,0.001341045,0.0003205053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00009506731,0.00003872056,0.0004251557,0.0008033258,0.00004417968,0.0004629191,0.0009964408,0.002122548,0.0005048228,0.9425395,0.01018152,0.04178574],"study_design_scores_gemma":[0.00001016071,0.00005131887,0.0003224261,0.000791068,0.00001700099,0.0002586962,0.0006489563,0.001232963,0.0003996259,0.8944857,0.1017361,0.00004611285],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01635041,0.6525329,0.05069399,0.2014217,0.01310936,0.0001051184,0.0002140575,0.0002163417,0.06535609],"genre_scores_gemma":[0.3187559,0.5895162,0.02263364,0.03258342,0.02599889,0.000373239,0.0001783786,0.0001595184,0.009800838],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01218305,"threshold_uncertainty_score":0.06443095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007167880173574357,"score_gpt":0.3284700813521019,"score_spread":0.3213022011785275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}