{"id":"W4414566467","doi":"10.1002/cctc.202500809","title":"Essential Logic and Facts Behind the Expansion of the Genetic Code: A Critical Assessment","year":2025,"lang":"en","type":"article","venue":"ChemCatChem","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Manitoba; Research Manitoba","keywords":"Genetic code; Amino acid; Translation (biology); Flexibility (engineering); Stop codon; Codon usage bias","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008452773,0.00009797778,0.0000919189,0.00001085986,0.00007474605,0.00001567603,0.0001815564,0.00008622944,0.000008193197],"category_scores_gemma":[0.00008122854,0.0000611658,0.00005657281,0.00005375126,0.0001568642,0.00000107462,0.000212889,0.00008952639,4.148081e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006444978,"about_ca_system_score_gemma":0.00007284231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000068585,"about_ca_topic_score_gemma":0.000009244383,"domain_scores_codex":[0.999424,0.00002123114,0.0001365867,0.000190816,0.00009106843,0.0001362622],"domain_scores_gemma":[0.9995305,0.00003037092,0.00002406473,0.0003389481,0.00004709452,0.0000290025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007395097,0.00002489807,0.001774715,0.00005719433,0.00002458358,4.554932e-7,0.00007769736,0.00004941917,0.995193,0.0002387972,0.0008100281,0.001741802],"study_design_scores_gemma":[0.0002028147,0.00002736106,0.03202411,0.00002258143,0.0000386643,0.000006282043,0.0001469708,0.0002093384,0.9647546,0.0003317774,0.002161383,0.00007413819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836646,0.001579406,0.01225422,0.001379346,0.0001893344,0.0001393831,0.000006576005,0.000005492224,0.0007816322],"genre_scores_gemma":[0.9983656,0.0001081779,0.0009429301,0.0002069533,0.00006350919,0.00001438511,0.000004842092,0.000007227136,0.0002863939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03043844,"threshold_uncertainty_score":0.2494269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007167880173574357,"score_gpt":0.3284700813521019,"score_spread":0.3213022011785275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}