{"id":"W4414568094","doi":"10.1101/2025.09.24.678140","title":"Nicotinic acetylcholine receptor signaling regulates cytokine production in Jurkat T cells","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University; Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Jurkat cells; Nicotinic agonist; T cell; Cytokine; Regulator; Nicotine; Signal transduction; Immune system; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002361309,0.0004081717,0.0003625471,0.0002217623,0.0002301819,0.0004895236,0.0001377961,0.0003285451,0.002794624],"category_scores_gemma":[0.000135013,0.000130915,0.0003246265,0.0003815586,0.0001450895,0.0002196311,0.0001571452,0.000898538,0.001539088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993383,"about_ca_system_score_gemma":0.0002196057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003474609,"about_ca_topic_score_gemma":0.0004418694,"domain_scores_codex":[0.999499,0.0001264892,0.00007151411,0.0001018066,0.00008015779,0.0001210752],"domain_scores_gemma":[0.9998989,0.00003011491,0.00001716958,0.00001599449,0.00001888991,0.00001897897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001693197,0.00005472379,0.0002772702,0.00004708191,0.00000577754,0.0000435788,0.00002463083,0.00005346897,0.9979113,0.00004953312,0.00008303737,0.001280308],"study_design_scores_gemma":[0.00005704681,0.0005957805,0.007623038,0.00001659935,0.00003103439,0.0002679168,0.0001196211,0.001586372,0.9862993,0.0001158736,0.003278268,0.00000917696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790034,0.003111082,0.008331675,0.000357771,0.0002025393,0.0001124024,0.002707145,0.0002330924,0.005941002],"genre_scores_gemma":[0.980786,0.002561604,0.006538996,0.0004026108,0.0001043317,0.0002215686,0.002433943,0.00003737035,0.006913585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002794624,"threshold_uncertainty_score":0.009348929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00940256099752987,"score_gpt":0.2322681975020295,"score_spread":0.2228656365044996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}