{"id":"W4414571485","doi":"10.17245/jdapm.2025.25.5.313","title":"Total intravenous sedation with target-controlled infusion in dentistry: clinical experience with the third-generation Eleveld pharmacokinetic/pharmacodynamic model","year":2025,"lang":"en","type":"article","venue":"Journal of Dental Anesthesia and Pain Medicine","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; University of Calgary; University of Alberta","funders":"","keywords":"Remifentanil; Sedation; Propofol; Intravenous sedation; Target controlled infusion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002111953,0.0003133409,0.0003127216,0.0001762571,0.0001476101,0.0006237006,0.000461095,0.0002531974,0.0008512407],"category_scores_gemma":[0.002293491,0.0001152378,0.0003885077,0.0002163893,0.0004724483,0.0003937629,0.0006728881,0.0009732608,0.0002339058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718543,"about_ca_system_score_gemma":0.0006022344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006781139,"about_ca_topic_score_gemma":0.0007140349,"domain_scores_codex":[0.9990844,0.0003855013,0.00006649371,0.00009139843,0.0002968913,0.00007534725],"domain_scores_gemma":[0.9991192,0.0003325627,0.0001818788,0.0001110583,0.0001310037,0.0001242305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005427137,0.005533869,0.06915031,0.0004649397,0.0002162975,0.001214361,0.002422973,0.007627357,0.108339,0.002298298,0.002004161,0.7953014],"study_design_scores_gemma":[0.003081356,0.2445414,0.3341427,0.0008144627,0.0009630652,0.0493912,0.002913831,0.08121429,0.182631,0.00303217,0.09673287,0.0005417567],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827257,0.003078955,0.01161397,0.0002995094,0.00002425823,0.0001266364,0.00002798829,0.00006838085,0.00203461],"genre_scores_gemma":[0.9757373,0.004877502,0.01810564,0.0002630343,0.00005104514,0.0001009308,0.00008949692,0.00003022692,0.0007448315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002111953,"threshold_uncertainty_score":0.01116925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02189022207402425,"score_gpt":0.3245571150363956,"score_spread":0.3026668929623714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}