{"id":"W4414571504","doi":"10.1002/ijc.70136","title":"Linkage disequilibrium score regression identifies genetic correlations between hepatocellular carcinoma and clinically relevant traits","year":2025,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Pancreas Centre (Canada)","funders":"National Institutes of Health; Cancer Prevention and Research Institute of Texas","keywords":"Linkage disequilibrium; Heritability; Hepatocellular carcinoma; Genome-wide association study; Genetic association; Disease; Genetic correlation; Liver disease; Liver cancer; Regression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004577823,0.000685301,0.0006112931,0.001394728,0.0003381971,0.0007352715,0.0004520277,0.000357884,0.002728381],"category_scores_gemma":[0.01830629,0.0002354685,0.0008609889,0.002161155,0.0005362869,0.0003555096,0.0007724757,0.0009037947,0.00036433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002906562,"about_ca_system_score_gemma":0.0006674411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00394088,"about_ca_topic_score_gemma":0.00342873,"domain_scores_codex":[0.9954582,0.002966698,0.0001764632,0.0008790988,0.0003341426,0.0001853236],"domain_scores_gemma":[0.987248,0.00924936,0.001802546,0.001084724,0.0003684752,0.0002469079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003859167,0.00008742487,0.9617086,0.00007468174,0.001519324,0.000352871,0.0001501585,0.005527973,0.003490384,0.001676528,0.0006367259,0.02438942],"study_design_scores_gemma":[0.00008157159,0.0003708412,0.9191324,0.00002888244,0.0006338393,0.0008390407,0.0001594463,0.06893221,0.00187196,0.005935329,0.001979175,0.00003533224],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9464417,0.0007892261,0.0488944,0.0003517121,0.00003126992,0.00004729832,0.001466865,0.0002493501,0.001728179],"genre_scores_gemma":[0.9951934,0.00009545284,0.003910166,0.00002988385,0.00001222258,0.0000235493,0.0004169714,0.00002471521,0.0002936036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004577823,"threshold_uncertainty_score":0.02421016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556924067882354,"score_gpt":0.3467794131289885,"score_spread":0.3212101724501649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}