{"id":"W4414574049","doi":"10.1016/j.ijrobp.2025.06.1270","title":"Hallmark Interferon-Alpha Response Analysis in Localized Prostate Cancer: Analysis of the NRG Oncology/RTOG 9202, 9413, 9902, 0126, and 0521 Clinical Trials","year":2025,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Juravinski Cancer Centre; Western University; Institute for Research in Immunology and Cancer; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Prostate cancer; Prostate; Clinical trial; Survival analysis; Multivariate analysis; Proportional hazards model; Prostatectomy; Disease; Biological response modifiers","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01392885,0.0005571502,0.001881336,0.0005933902,0.0001858873,0.0009073802,0.0007528462,0.0005697529,0.003309565],"category_scores_gemma":[0.009219382,0.0002831576,0.002452944,0.0009751488,0.0005392298,0.001107732,0.0005544392,0.001698997,0.000490787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001040991,"about_ca_system_score_gemma":0.001238051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005308962,"about_ca_topic_score_gemma":0.001861474,"domain_scores_codex":[0.9951213,0.003579668,0.0003189445,0.0004001765,0.0003972246,0.0001826947],"domain_scores_gemma":[0.991515,0.00415626,0.002068757,0.001226894,0.0003540148,0.0006789594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6348353,0.002500096,0.09813523,0.00170803,0.01583421,0.0001087703,0.0001854525,0.00489267,0.01019247,0.0006416813,0.006787205,0.2241789],"study_design_scores_gemma":[0.2511546,0.181322,0.5147464,0.0004505767,0.01916641,0.001020287,0.0002835141,0.008322492,0.006154699,0.002274971,0.01494029,0.0001638247],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977371,0.01184649,0.001228617,0.0007482579,0.00008030184,0.0006090535,0.004186494,0.0002079571,0.003721837],"genre_scores_gemma":[0.9906673,0.001803262,0.001999586,0.0005568165,0.00007112503,0.0003503141,0.003300684,0.0000437422,0.001207218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01392885,"threshold_uncertainty_score":0.07366365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06840269820230187,"score_gpt":0.4868278750349292,"score_spread":0.4184251768326273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}