{"id":"W4414580704","doi":"10.1158/1538-7445.pancreatic25-b049","title":"Abstract B049: Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose <i>de novo</i> lipogenesis","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Lipogenesis; Cachexia; Wasting; Adipose tissue; Pancreatic cancer; Cancer; Regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510941,0.0004022683,0.000289437,0.0003396999,0.0003562907,0.0005813587,0.0004628711,0.000471246,0.007887408],"category_scores_gemma":[0.00009299904,0.0002331885,0.0004046072,0.0002478446,0.0004788022,0.0002627459,0.0003396081,0.001356815,0.002016163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004451471,"about_ca_system_score_gemma":0.000460735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009630866,"about_ca_topic_score_gemma":0.0009802586,"domain_scores_codex":[0.9998413,0.00001537374,0.00001374945,0.00003584332,0.00005973969,0.00003401347],"domain_scores_gemma":[0.9999142,0.000008490915,0.00002542725,0.00001073929,0.000008208059,0.00003293083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002922302,0.00006713863,0.0001498505,0.00008671721,0.000008028728,0.0001552177,0.00001435148,0.00007336644,0.994971,0.0006805688,0.0007351174,0.002766251],"study_design_scores_gemma":[0.0001156012,0.0005593759,0.005206698,0.00003306973,0.00002987465,0.001044137,0.00006414534,0.0007665409,0.9707251,0.0002843601,0.02115657,0.00001460558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9245812,0.007307346,0.02178108,0.004119412,0.001330045,0.0003036596,0.00679937,0.001849453,0.03192842],"genre_scores_gemma":[0.9406388,0.004299561,0.006647443,0.0007843482,0.0001093835,0.0002471809,0.003364246,0.0002406281,0.04366848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007887408,"threshold_uncertainty_score":0.02638596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828369661505261,"score_gpt":0.3690996843203203,"score_spread":0.3408159877052677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}