{"id":"W4414582304","doi":"10.1158/1538-7445.pancreatic25-a114","title":"Abstract A114: CCK-B Receptor Blockade with Proglumide Enhances Antitumor Activity and Persistence of CD8+CD161+ CAR-T Cells in Pancreatic Ductal Adenocarcinoma","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"CD8; Immunotherapy; Tumor microenvironment; Immune system; T cell; Receptor; Flow cytometry; Proglumide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090369,0.0002779952,0.0003377618,0.0001590744,0.00009539508,0.0002277176,0.0001687662,0.0002276623,0.002136212],"category_scores_gemma":[0.00008196856,0.0000923658,0.0002245364,0.0001075202,0.0001697197,0.00015743,0.0001222677,0.0007906209,0.0005009675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001658821,"about_ca_system_score_gemma":0.0002113757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003950848,"about_ca_topic_score_gemma":0.0004247892,"domain_scores_codex":[0.9998882,0.00001940299,0.00001330175,0.00002110658,0.00001978796,0.00003817522],"domain_scores_gemma":[0.9999385,0.000009650843,0.00001233172,0.000008707674,0.000005209701,0.00002562422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009002927,0.0004298381,0.0002202993,0.0000593359,0.000007529842,0.00005631403,0.00001707807,0.0001244531,0.993664,0.00006110633,0.0001715251,0.00428823],"study_design_scores_gemma":[0.0002731065,0.007727399,0.004590559,0.00000697686,0.00003498108,0.000313002,0.00003057378,0.001248147,0.982565,0.00003511383,0.003169596,0.000005350135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972919,0.0006818001,0.0005427729,0.00006953446,0.00004490244,0.00003488519,0.000214104,0.00007369954,0.001046439],"genre_scores_gemma":[0.9954686,0.0003645207,0.000709096,0.00004847608,0.00002027432,0.00007608611,0.0004314886,0.00001122583,0.002870307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002136212,"threshold_uncertainty_score":0.007146299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05291562931985745,"score_gpt":0.3681261127798817,"score_spread":0.3152104834600243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}