{"id":"W4414585568","doi":"10.1158/1538-7445.pancreatic25-b002","title":"Abstract B002: Effects of Proglumide with Chemotherapy on the Pancreatic Tumor Microenvironment: Phase 1 PROGEM Trial","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemotherapy; Proglumide; Phases of clinical research; Biopsy; Biomarker; Cancer; Immunohistochemistry; Tumor microenvironment","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009624321,0.001038405,0.0008910783,0.0002517281,0.0002902939,0.001011166,0.0005931383,0.001342919,0.008169058],"category_scores_gemma":[0.0008117746,0.0003776154,0.0009297653,0.0002705986,0.0005252573,0.0006401861,0.0003346698,0.002642952,0.001434905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004509487,"about_ca_system_score_gemma":0.001024986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003285918,"about_ca_topic_score_gemma":0.0007783177,"domain_scores_codex":[0.9997638,0.000117749,0.0000106883,0.00004713226,0.00002413298,0.00003650166],"domain_scores_gemma":[0.9996421,0.00005823246,0.00007767517,0.00003759064,0.00002949896,0.0001547735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7936003,0.04154879,0.00445837,0.002085941,0.001311712,0.0003634848,0.0001595229,0.001016539,0.0318489,0.0005223713,0.01346491,0.1096192],"study_design_scores_gemma":[0.6139942,0.3610395,0.007645607,0.0001085425,0.0004932069,0.0004243611,0.00005900288,0.0005412754,0.003854206,0.0004344963,0.01138054,0.00002506028],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715217,0.007284768,0.0008288893,0.002273706,0.0003259446,0.00505378,0.005606765,0.0002804189,0.006823998],"genre_scores_gemma":[0.9614122,0.005132095,0.002614425,0.003226789,0.0005583434,0.007575687,0.007473178,0.00008364347,0.01192361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008169058,"threshold_uncertainty_score":0.02732819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02864626964895328,"score_gpt":0.3688657551176556,"score_spread":0.3402194854687023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}