{"id":"W4414587150","doi":"10.1101/2025.09.28.678669","title":"Directed evolution of a compact TranC11a system for efficient genome editing","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Genetics","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Genome editing; Zinc finger nuclease; Genome; Transposable element; Human genome; Directed evolution; DNA Transposable Elements","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004137117,0.0005542786,0.0004032443,0.0003303076,0.0002009484,0.0006605774,0.000482332,0.0005109946,0.001642644],"category_scores_gemma":[0.0003660193,0.0003139635,0.0004026416,0.0003055365,0.0002622236,0.0003062533,0.0006909832,0.00124456,0.0009851167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004638379,"about_ca_system_score_gemma":0.0002367065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003911835,"about_ca_topic_score_gemma":0.0004346697,"domain_scores_codex":[0.9997107,0.00004268658,0.00003705479,0.00007100924,0.00009318593,0.00004524905],"domain_scores_gemma":[0.9997153,0.00005432133,0.00008291755,0.00004868093,0.00003653667,0.00006213093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004279012,0.00002410199,0.0001129898,0.00003212418,0.00001035325,0.00006995464,0.00001520705,0.0003700386,0.9968482,0.000451871,0.0001022633,0.001920245],"study_design_scores_gemma":[0.00001755187,0.00008521973,0.0005845161,0.000008205304,0.00001331055,0.00023604,0.00001262268,0.005015283,0.9880254,0.00008471467,0.005903418,0.00001376052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9143721,0.0006539694,0.07788995,0.0002764492,0.000175988,0.0002221455,0.001604995,0.001220031,0.00358429],"genre_scores_gemma":[0.9504692,0.0004844984,0.03954532,0.00009235317,0.0000199936,0.0001317377,0.002289655,0.0005649996,0.006402351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642644,"threshold_uncertainty_score":0.005495191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006608572911224055,"score_gpt":0.2366629656743949,"score_spread":0.2300543927631709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}