{"id":"W4414588684","doi":"10.1093/cei/uxaf065","title":"Serum sBCMA in primary and secondary antibody deficiency","year":2025,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"UK Research and Innovation","keywords":"Common variable immunodeficiency; Antibody; Biomarker; Asymptomatic; Immune system; Hypogammaglobulinemia; Humoral immunity; Primary immunodeficiency; Immunopathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182651,0.0001438885,0.0002447111,0.00004984618,0.00006113651,0.00001220359,0.0001415646,0.0002534087,0.00003458986],"category_scores_gemma":[0.00003124818,0.000137282,0.00007812005,0.00007811195,0.0003292316,0.000005137695,0.0003282671,0.0001570686,0.00001214384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001493129,"about_ca_system_score_gemma":0.00008839273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002605642,"about_ca_topic_score_gemma":0.00001006862,"domain_scores_codex":[0.9988434,0.00009940978,0.0003551001,0.0004311023,0.00003478029,0.000236248],"domain_scores_gemma":[0.9996079,0.00002850797,0.0000500806,0.0002658723,0.00001372592,0.00003392631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005022471,0.002758957,0.3941777,0.00002066886,0.0002214024,0.00003236673,0.00006294339,4.790388e-7,0.553634,0.001258649,0.0006218257,0.04670866],"study_design_scores_gemma":[0.007318616,0.001733415,0.7814659,0.00003163978,0.00002701734,0.00002412458,0.0005176627,0.00000539899,0.197643,0.0003813328,0.01055056,0.0003013564],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531967,0.03613128,0.00002263175,0.0001693537,0.0003435542,0.0001671987,0.000007692806,0.00001023193,0.009951341],"genre_scores_gemma":[0.996856,0.001187946,0.0001741297,0.001136929,0.00002173109,0.00002427601,0.0000949004,0.000009852361,0.000494277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3872881,"threshold_uncertainty_score":0.5598196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01009430363745228,"score_gpt":0.3500598340677615,"score_spread":0.3399655304303092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}