{"id":"W4414594486","doi":"10.1097/hc9.0000000000000796","title":"Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition","year":2025,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute on Minority Health and Health Disparities; National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Proteome; Transition (genetics); Epithelial–mesenchymal transition; Focus (optics); Proteomics; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009988581,0.0001791447,0.0003277234,0.0005360051,0.0002366966,0.00001351471,0.0002986722,0.0001363694,0.00003436801],"category_scores_gemma":[0.00007229883,0.0001600011,0.00007765421,0.001263801,0.0001187828,0.00009844943,0.0001201838,0.0002930062,0.0001051158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678881,"about_ca_system_score_gemma":0.0005100719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004941098,"about_ca_topic_score_gemma":0.0009988761,"domain_scores_codex":[0.9987434,0.0001610653,0.0003638642,0.0003196941,0.0001221172,0.000289919],"domain_scores_gemma":[0.9981894,0.0002196416,0.00006825589,0.001209681,0.0001385548,0.0001744733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000462537,0.001810165,0.9819782,0.00009809584,0.0001093747,0.00007718238,0.0005102804,0.00005807472,0.00005616882,0.002559732,0.0004287857,0.01185134],"study_design_scores_gemma":[0.003155001,0.0001648084,0.9897657,0.00005672176,0.0006722121,0.00007637732,0.00007616866,0.003118218,0.00003957815,0.0001959988,0.002496039,0.0001831756],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834434,0.0004099325,0.001169487,0.0109577,0.0000453408,0.001520312,0.0001381493,0.00009872171,0.002216922],"genre_scores_gemma":[0.9934705,0.001018775,0.003455796,0.0005457837,0.00002654409,0.001004575,0.0002641722,0.00001653024,0.0001972651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01166816,"threshold_uncertainty_score":0.6524657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02072309825473416,"score_gpt":0.2980951269572326,"score_spread":0.2773720287024984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}