{"id":"W4414595530","doi":"10.1371/journal.ppat.1013549","title":"The tegument protein VP22 of pseudorabies virus inhibits cGAS condensation by inducing nuclear-to-cytoplasmic translocation of DDX21","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Pseudorabies; Viral tegument; Innate immune system; Helicase; Virus; Viral replication; Antiviral protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037892,0.0003766325,0.0001934984,0.00009145745,0.0001116551,0.0002741863,0.0001570882,0.000201819,0.0005879343],"category_scores_gemma":[0.00008521094,0.00008607162,0.0001595727,0.00006216492,0.0002189156,0.0001732145,0.0001733835,0.0003418558,0.0002061023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00023121,"about_ca_system_score_gemma":0.0001479056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002791942,"about_ca_topic_score_gemma":0.0003271726,"domain_scores_codex":[0.999909,0.00002000974,0.000007704662,0.00001392906,0.00002546575,0.00002374349],"domain_scores_gemma":[0.999954,0.000008448668,0.00001425008,0.000007662704,0.000003678237,0.000011854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004487117,0.00001661751,0.00007835902,0.00001352995,0.000003026859,0.00002151298,0.000004133326,0.00004628834,0.999063,0.00007454997,0.00001552371,0.0006186821],"study_design_scores_gemma":[0.000006373855,0.0001646075,0.001276171,0.000001389069,0.000003708821,0.0001096831,0.000006533488,0.000575453,0.996904,0.00002081457,0.0009297869,0.00000157479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995889,0.001395474,0.001650105,0.00005593157,0.00001992473,0.00001488649,0.00007485493,0.00004621562,0.0008535373],"genre_scores_gemma":[0.9969631,0.0004865089,0.001132009,0.00002799732,0.000007269114,0.00001435922,0.0001972283,0.00001134736,0.001160316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005879343,"threshold_uncertainty_score":0.001966834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007284380424322332,"score_gpt":0.2224203993982898,"score_spread":0.2151360189739674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}