{"id":"W4414598279","doi":"10.1101/2025.09.26.678871","title":"Neutrophil Extracellular Traps Mediate <i>In Vitro</i> and <i>In Vivo</i> Degradation of α-Synuclein Amyloid Fibrils","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"","keywords":"Neutrophil extracellular traps; Proteases; Elastase; Neutrophil elastase; Extracellular; Lung; Fibril; Cathepsin G; Myeloperoxidase; Amyloid (mycology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003831051,0.0006404509,0.0002338536,0.0001647676,0.0001084851,0.00027142,0.0001518389,0.0003520863,0.001510945],"category_scores_gemma":[0.0001715766,0.0001716737,0.0004633419,0.0000757748,0.0002074293,0.0002769473,0.0001826928,0.0006295543,0.0004341465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001427602,"about_ca_system_score_gemma":0.0001114631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002520375,"about_ca_topic_score_gemma":0.0002352948,"domain_scores_codex":[0.9996483,0.00008377183,0.00004153972,0.00005641676,0.00005867635,0.0001112064],"domain_scores_gemma":[0.9998112,0.00003291862,0.00007467414,0.00002249711,0.00002430479,0.00003435137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002251239,0.00005894984,0.00009623458,0.00005246569,0.00000668528,0.00005216833,0.00001044222,0.000031411,0.9990195,0.00004377915,0.00004525375,0.0003579578],"study_design_scores_gemma":[0.00002288581,0.0005422099,0.001876795,0.00001044909,0.00001141864,0.000210408,0.00001993784,0.0004899349,0.9962156,0.00002918869,0.0005686776,0.000002382214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908184,0.002125328,0.004399754,0.0001573445,0.00007745298,0.00007703823,0.0005001031,0.00009395669,0.001750476],"genre_scores_gemma":[0.9946562,0.0007684435,0.00160286,0.00009751739,0.00002835021,0.00005990686,0.0005731098,0.00001733081,0.002196289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510945,"threshold_uncertainty_score":0.005054653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548485102737787,"score_gpt":0.2456310419774485,"score_spread":0.2301461909500706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}