{"id":"W4414608223","doi":"10.3390/curroncol32100546","title":"Natural and Synthetic Compounds Against Colorectal Cancer: An Update of Preclinical Studies in Saudi Arabia","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Colorectal cancer; In vivo; Translational research; Cancer; PI3K/AKT/mTOR pathway; Clinical trial; Epidermal growth factor receptor; Pharmacokinetics; Drug","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001090666,0.00074412,0.0008766559,0.001764402,0.0002882226,0.0006984683,0.0005028872,0.0005921532,0.002893321],"category_scores_gemma":[0.0008638448,0.0002992598,0.0007179101,0.001396861,0.000345446,0.0009610733,0.0004984247,0.001098887,0.0007499887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005043003,"about_ca_system_score_gemma":0.001000946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001810476,"about_ca_topic_score_gemma":0.004559021,"domain_scores_codex":[0.9998237,0.00003224795,0.00003893719,0.00002330985,0.00006144497,0.00002020395],"domain_scores_gemma":[0.9993647,0.0001875621,0.0001193332,0.00002259092,0.0002585658,0.00004734406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001166717,0.0008633024,0.001782061,0.02400717,0.0004137026,0.0005235008,0.0002667516,0.001132544,0.03656673,0.001433716,0.01085595,0.9209878],"study_design_scores_gemma":[0.0004172291,0.00752725,0.008483292,0.003928636,0.001693689,0.002455557,0.0003320518,0.0006088807,0.02482414,0.0008584408,0.9487764,0.00009446483],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009754317,0.9859675,0.0004442927,0.0005764667,0.0001960868,0.00006841825,0.0002872221,0.00002856223,0.002677204],"genre_scores_gemma":[0.02143648,0.9750944,0.0009398062,0.0006034797,0.0001292902,0.00004250286,0.0004326251,0.00000760021,0.001313708],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002893321,"threshold_uncertainty_score":0.009679139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06412377035552312,"score_gpt":0.4156770599580282,"score_spread":0.351553289602505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}