{"id":"W4414608613","doi":"10.1038/s41467-025-63585-x","title":"A newborn derived monoclonal IgM antibody selectively modulates microbial metabolism in the gut","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Infant Nutrition and Health","field":"Nursing","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China-Yunnan Joint Fund; National Natural Science Foundation of China","keywords":"Gut flora; Metabolome; Monoclonal antibody; Microbial metabolism; Immune system; Antibody; Bacteria; Metabolism; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944704,0.0002946345,0.0001667559,0.0001982617,0.00008367562,0.0001748323,0.0001740116,0.000265374,0.000759237],"category_scores_gemma":[0.0001570652,0.00008358423,0.0001538452,0.00008489883,0.0001177272,0.0001153091,0.0001529858,0.0003843758,0.0001563579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002156391,"about_ca_system_score_gemma":0.0001341449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003151057,"about_ca_topic_score_gemma":0.0004481424,"domain_scores_codex":[0.9998504,0.00003117169,0.00001064255,0.00002966638,0.00003822124,0.00003988323],"domain_scores_gemma":[0.9999092,0.0000141489,0.00002688417,0.000008136395,0.00001628609,0.00002528016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007958578,0.0000292837,0.0001627197,0.000013396,0.000001921953,0.00001377804,0.000005183644,0.00002119087,0.9984409,0.00002262142,0.00002213232,0.00118722],"study_design_scores_gemma":[0.00002079159,0.001394302,0.003782568,0.000006722212,0.00002095418,0.0001740832,0.00001750241,0.0003828926,0.9923769,0.00001920298,0.001800521,0.000003557869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952715,0.0008198391,0.002579636,0.00007501683,0.0000264621,0.0000365899,0.000147776,0.00006605544,0.0009771344],"genre_scores_gemma":[0.9939895,0.0006006508,0.003104712,0.0001404652,0.00001541509,0.000045042,0.0002978468,0.0000168759,0.001789587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000759237,"threshold_uncertainty_score":0.002539933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757931549233895,"score_gpt":0.3531520374111068,"score_spread":0.3355727219187679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}