{"id":"W4414616244","doi":"10.1183/23120541.00616-2025","title":"Neutrophilic asthma may not be a distinct endotype","year":2025,"lang":"en","type":"letter","venue":"ERJ Open Research","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton; Western University","funders":"","keywords":"Neutrophilia; Endotype; Asthma; Airway; Neutrophile; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006966462,0.0005122081,0.0007285543,0.0004032918,0.001151788,0.001425036,0.0006685099,0.01071697,0.01213338],"category_scores_gemma":[0.005053847,0.0002479682,0.0005456725,0.00033404,0.001583378,0.002265969,0.0005201954,0.009331839,0.007577137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001548341,"about_ca_system_score_gemma":0.0006999633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044676,"about_ca_topic_score_gemma":0.001599508,"domain_scores_codex":[0.999365,0.0001664354,0.00008685638,0.0001338524,0.0001271298,0.0001207002],"domain_scores_gemma":[0.9987764,0.0006647966,0.0001452158,0.00006150477,0.0001782303,0.0001738141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000247276,0.0001060681,0.008539283,0.0003217563,0.00003800499,0.1462045,0.0003121336,0.0001203368,0.001345345,0.01318623,0.7923702,0.03720894],"study_design_scores_gemma":[0.0002141491,0.0001892713,0.01255501,0.0009182494,0.00006017063,0.3534379,0.001124451,0.0008991438,0.0006911554,0.02709477,0.6027431,0.00007267439],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01254644,0.01106163,0.000635955,0.9014173,0.03655266,0.00007377816,0.0001770555,0.00009918066,0.03743604],"genre_scores_gemma":[0.1145955,0.01019411,0.0009174914,0.5931662,0.2486072,0.00007983627,0.0001657885,0.00008155054,0.03219229],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01213338,"threshold_uncertainty_score":0.04059023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1467115927712209,"score_gpt":0.4390939212870431,"score_spread":0.2923823285158221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}