{"id":"W4414624433","doi":"10.1021/jacs.5c05892","title":"Nucleotide-Specific RNA Conformations and Dynamics as Precursors to Ribonucleoprotein Condensates","year":2025,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Ribonucleoprotein; RNA; Molecular dynamics; Nucleic acid structure; Ribonucleoprotein particle; Dynamics (music); Transcription (linguistics); RNA-binding protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102773,0.0001565657,0.0001799609,0.0001723589,0.000173011,0.0004171988,0.0001627951,0.0001289426,0.0007698368],"category_scores_gemma":[0.0004138109,0.0001663031,0.0000924705,0.0001631374,0.0002579474,0.0003062501,0.0001855069,0.0003010873,0.0001760505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004263684,"about_ca_system_score_gemma":0.0001943054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264398,"about_ca_topic_score_gemma":0.001561168,"domain_scores_codex":[0.9999372,0.000007920989,0.000002753875,0.00001686486,0.00002486148,0.00001043471],"domain_scores_gemma":[0.999882,0.00004116551,0.00002130998,0.000008298395,0.00001794989,0.00002920018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001073562,0.00002609317,0.001583642,0.00004207818,0.00001344768,0.0001205442,0.0001462647,0.007720476,0.9851463,0.001846564,0.00007244178,0.003174745],"study_design_scores_gemma":[0.00002364474,0.0001716553,0.007043105,0.000009271519,0.00001187366,0.00009289632,0.0001244575,0.08275249,0.9068868,0.0007776759,0.002084584,0.00002164101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995212,0.0002881546,0.003452699,0.00002764515,0.000008281271,0.00001265768,0.00007208551,0.00005691838,0.0008696702],"genre_scores_gemma":[0.9968213,0.0002277274,0.001881485,0.00001277392,0.000003197139,0.00001279666,0.000141724,0.00003411691,0.0008648354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001264398,"threshold_uncertainty_score":0.003093541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005397518744043358,"score_gpt":0.2518295562695344,"score_spread":0.2464320375254911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}